Seroatlas · Human Serome Atlas

UNC45A

Protein unc-45 homolog A

Also known as: GC-UNC45, SMAP-1, UN45A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H3U1
Gene
UNC45A
Ensembl
ENSG00000140553
Chromosome
15
Canonical length
944 aa
Protein class
Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of myosin during development of muscle cells. [provided by RefSeq, Sep 2018]

Canonical amino-acid sequenceUniProt

944 residues, UniProt reviewed canonical sequence.

>Q9H3U1|UNC45A
     1  MTVSGPGTPE PRPATPGASS VEQLRKEGNE LFKCGDYGGA LAAYTQALGL DATPQDQAVL
    61  HRNRAACHLK LEDYDKAETE ASKAIEKDGG DVKALYRRSQ ALEKLGRLDQ AVLDLQRCVS
   121  LEPKNKVFQE ALRNIGGQIQ EKVRYMSSTD AKVEQMFQIL LDPEEKGTEK KQKASQNLVV
   181  LAREDAGAEK IFRSNGVQLL QRLLDMGETD LMLAALRTLV GICSEHQSRT VATLSILGTR
   241  RVVSILGVES QAVSLAACHL LQVMFDALKE GVKKGFRGKE GAIIVDPARE LKVLISNLLD
   301  LLTEVGVSGQ GRDNALTLLI KAVPRKSLKD PNNSLTLWVI DQGLKKILEV GGSLQDPPGE
   361  LAVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIK SWFEGQGLAG KLRAIQTVSC
   421  LLQGPCDAGN RALELSGVME SVIALCASEQ EEEQLVAVEA LIHAAGKAKR ASFITANGVS
   481  LLKDLYKCSE KDSIRIRALV GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNDQID
   541  AGTRRWAVEG LAYLTFDADV KEEFVEDAAA LKALFQLSRL EERSVLFAVA SALVNCTNSY
   601  DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL AAGVVSAMVC MVKTESPVLT
   661  SSCRELLSRV FLALVEEVED RGTVVAQGGG RALIPLALEG TDVGQTKAAQ ALAKLTITSN
   721  PEMTFPGERI YEVVRPLVSL LHLNCSGLQN FEALMALTNL AGISERLRQK ILKEKAVPMI
   781  EGYMFEEHEM IRRAATECMC NLAMSKEVQD LFEAQGNDRL KLLVLYSGED DELLQRAAAG
   841  GLAMLTSMRP TLCSRIPQVT THWLEILQAL LLSSNQELQH RGAVVVLNMV EASREIASTL
   901  MESEMMEILS VLAKGDHSPV TRAAAACLDK AVEYGLIQPN QDGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC45A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 50 nTPM
  • urinary bladder: 41 nTPM
  • colon: 38 nTPM
  • skin: 36 nTPM
  • endometrium: 35 nTPM
  • seminal vesicle: 32 nTPM

Single-cell type

  • retinal ganglion cells: 124 nCPM
  • megakaryocytes: 87 nCPM
  • cardiomyocytes: 81 nCPM
  • platelets: 75 nCPM
  • cytotrophoblasts: 66 nCPM
  • esophageal suprabasal cells: 61 nCPM

Immune cell

  • gdT-cell: 12 nTPM
  • non-classical monocyte: 12 nTPM
  • basophil: 12 nTPM
  • MAIT T-cell: 11 nTPM
  • myeloid DC: 10 nTPM
  • NK-cell: 9.8 nTPM

Brain region

  • midbrain: 20 nTPM
  • choroid plexus: 17 nTPM
  • thalamus: 16 nTPM
  • pons: 15 nTPM
  • medulla oblongata: 14 nTPM
  • cerebellum: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UNC45A.

Disease | AllUniProt

Conditions UNC45A is implicated in, by any mechanism.

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 749 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Osteootohepatoenteric syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
0.19
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UNC45A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UNC45A as an antibody target. Whether an autoantibody or antibody against UNC45A could matter depends on whether native UNC45A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UNC45A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UNC45A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UNC45A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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