Seroatlas · Human Serome Atlas

FAM83C

Protein FAM83C

Also known as: C20orf128, dJ614O4.7, FA83C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BQN1
Gene
FAM83C
Ensembl
ENSG00000125998
Chromosome
20
Canonical length
747 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the family with sequence similarity 83 protein family. The encoded protein may be involved in regulating MAPK signaling in cancer cells. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>Q9BQN1|FAM83C
     1  MFGGPGPGVL GAQGMAGPLR GRVEELKLPW WRESSPLVLR HSEAARLAAD ALLERGEAAY
    61  LRVISEEREL PFLSALDVDY MTSHVRGGPE LSEAQGQEAS GPDRLSLLSE VTSGTYFPMA
   121  SDIDPPDLDL GWPEVPQATG FSPTQAVVHF QRDKAKNIKD LLRFLFSQAH TVVAVVMDIF
   181  TDMELLCDLM EASSRRGVPV YLLLAQEHLR HFLEMCYKMD LNGEHLPNMR VRSTCGDTYC
   241  SKAGRRFTGQ ALEKFVLIDC EQVVAGSYSF TWLCSQAHTS MVLQLRGRIV EDFDREFRCL
   301  YAESQPVEGF CGGEDPLSPR ALRPPPVALA FRPDVPSPTS SLPSSTSLSS IKQSPLMGRS
   361  SYLALPGGGD CSDTGVVSSS LGPARREASG QPSLHRQLSD PNHGSPPGLY RANLGKLGAY
   421  PWSQSSPALN HNSTSPLTLA VGSPLLPRSR PLLQFHRGAP ALSRFPENGL PGSQEPSPLR
   481  GRWVPGTTLE TVEEKEKKAS PSQSRGQLDL LVPFPRAREV GDPDSGVTPN SGPLRPGEQA
   541  PEDRRLSPSQ ADSQLDLLSR ALGTGGAPEL GSLRPGDRAL EDRRLSLNQS RGQSDLLMQY
   601  PKAQGSRVPL ETNSSARPAR RAPDERRQTL GHSQLDLITK FGPFRGEGPG PNGLPISSPA
   661  RTAGAGSGDE KRLTLGHSKL DLITKYHQLH GARQGTEPGG PKGGHLNGGN SDLVRDEKRL
   721  TLGHSKLDLI TKYNKSKFKQ LRSRFES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM83C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • skin: 40 nTPM
  • esophagus: 32 nTPM
  • vagina: 14 nTPM
  • cervix: 10 nTPM
  • salivary gland: 3.8 nTPM
  • tonsil: 1.9 nTPM

Single-cell type

  • suprabasal keratinocytes: 67 nCPM
  • esophageal suprabasal cells: 65 nCPM
  • esophageal basal cells: 46 nCPM
  • esophageal apical cells: 44 nCPM
  • basal keratinocytes: 29 nCPM
  • early spermatids: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.9 nTPM
  • medulla oblongata: 0.9 nTPM
  • pons: 0.9 nTPM
  • thalamus: 0.9 nTPM
  • amygdala: 0.8 nTPM
  • choroid plexus: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0
gnomAD missense Z
-0.11
DepMap mean gene effect
-0.23
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM83C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM83C as an antibody target. Whether an autoantibody or antibody against FAM83C could matter depends on whether native FAM83C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM83C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM83C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM83C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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