Seroatlas · Human Serome Atlas

PPP1R14A

Protein phosphatase 1 regulatory subunit 14A

Also known as: CPI-17, PP14A_HUMAN, PPP1INL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A00
Gene: PPP1R14A
Ensembl: ENSG00000167641
Chromosome: 19
Canonical length: 147 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>Q96A00|PPP1R14A
     1  MAAQRLGKRV LSKLQSPSRA RGPGGSPGGL QKRHARVTVK YDRRELQRRL DVEKWIDGRL
    61  EELYRGMEAD MPDEINIDEL LELESEEERS RKIQGLLKSC GKPVEDFIQE LLAKLQGLHR
   121  QPGLRQPSPS HDGSLSPLQD RARTAHP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R14A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 1,610 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 1,610 nTPM
spinal cord: 861 nTPM
colon: 552 nTPM
midbrain: 501 nTPM
urinary bladder: 396 nTPM
hippocampal formation: 344 nTPM

Single-cell type

megakaryocytes: 1,156 nCPM
vascular smooth muscle cells: 1,021 nCPM
hepatic stellate cells: 994 nCPM
smooth muscle cells: 957 nCPM
decidual stromal cells: 649 nCPM
peritubular myoid cells: 596 nCPM

Immune cell

memory B-cell: 301 nTPM
naive B-cell: 286 nTPM
plasmacytoid DC: 248 nTPM
myeloid DC: 45 nTPM
total PBMC: 22 nTPM
basophil: 12 nTPM

Brain region

white matter: 896 nTPM
medulla oblongata: 748 nTPM
thalamus: 662 nTPM
basal ganglia: 616 nTPM
cerebellum: 577 nTPM
midbrain: 576 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0.13
gnomAD missense Z: 0.56
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R14A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CSNK1A1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R14A as an antibody target. Whether an autoantibody or antibody against PPP1R14A could matter depends on whether native PPP1R14A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R14A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R14A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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