Seroatlas · Human Serome Atlas

ZDBF2

DBF4-type zinc finger-containing protein 2

Also known as: FLJ45338, KIAA1571, ZDBF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCK1
Gene
ZDBF2
Ensembl
ENSG00000204186
Chromosome
2
Canonical length
2354 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein containing DBF4-type zinc finger domains. This gene is imprinted and paternally expressed in lymphocytes but is more stochastically expressed in the placenta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

2354 residues, UniProt reviewed canonical sequence.

>Q9HCK1|ZDBF2
     1  MQKRQGYCSY CRVQYNNLEQ HLFSAQHRSL TRQSRRQICT SSLMERFLQD VLQHHPYHCQ
    61  ESSSTQDETH VNTGSSSEVV HLDDAFSEEE EEDEDKVEDE DATEERPSEV SEPIEELHSR
   121  PHKSQEGTQE VSVRPSVIQK LEKGQQQPLE FVHKIGASVR KCNLVDIGQA TNNRSNLVRP
   181  PVICNAPASC LPESSNDRPV TANTTSLPPA AHLDSVSKCD PNKVEKYLEQ PDGASRNPVP
   241  SSHVETTSFS YQKHKESNRK SLRMNSDKLV LWKDVKSQGK TLSAGLKFHE RMGTKGSLRV
   301  KSPSKLAVNP NKTDMPSNKG IFEDTIAKNH EEFFSNMDCT QEEKHLVFNK TAFWEQKCSV
   361  SSEMKFDCIS LQSASDQPQE TAQDLSLWKE EQIDQEDNYE SRGSEMSFDC SSSFHSLTDQ
   421  SKVSAKEVNL SKEVRTDVQY KNNKSYVSKI SSDCDDILHL VTNQSQMIVK EISLQNARHI
   481  SLVDQSYESS SSETNFDCDA SPQSTSDYPQ QSVTEVNLPK EVHIGLVDKN YGSSSSEVSA
   541  DSVFPLQSVV DRPPVAVTET KLRKKAHTSL VDNYGSSCSE TSFDCDVSLE SVVDHPQLTV
   601  KGRNLKGRQV HLKHKKRKPS SAKAHLDCDV SLGTVADESQ RAVEKINLLK EKNADLMDMN
   661  CESHGPEMGF QADAQLADQS QVAEIERQKV DVDLENKSVQ SSRSSLSSDS PASLYHSAHD
   721  EPQEALDEVN LKELNIDMEV RSYDCSSSEL TFDSDPPLLS VTEQSHLDAE GKERHIDLED
   781  ESCESDSSEI TFDSDIPLYS VIDQPEVAVY EEETVDLESK SNESCVSEIT FDSDIPLHSG
   841  NDHPEVAVKE VIQKEEYIHL ERKNDEPSGS EISSDSHAPL HSVTNSPEVA VKKLNPQKEE
   901  QVHLENKENE PIDSEVSLDY NIIFHSVTGR SEDPIKEISL HTKEHMYLEN KSVFETSLDS
   961  DVPLQAATHK PEVIVKETWL QREKHAEFQG RSTEFSGSKT SLDSGVPHYS VTEPQVAVNK
  1021  INRKKQYVLE NKNDKCSGSE IILDSNVPPQ SMTDQPQLAF LKEKHVNLKD KNSKSGDSKI
  1081  TFDSEQLQEA VKKIDQWKEE VIGLKNKINE PSTYKLIHHP DVSVQSVADQ PKVAIKHVNL
  1141  GNENHMYLEV KNSQYSCSEM NLDSGFLGQS IVNRPQITIL EQEHIELEGK HNQCCGSEVS
  1201  FDSDDPLQSV ADRLRETVKE ISLWKDEEVD TEDRRNEAKG FEIMYDSDVL QPVAGQPEEV
  1261  VKEVSLWKEH VDLENKIVKP TDSRINFDSH EPLQSVTNKI PGANKEINLL REEHVCLDDK
  1321  GYVPSDSEII YVSNIPLQSV IKQPHILEEE HASLEDKSSN SYSPEESSDS NDSFQAAADE
  1381  LQKPVKEINL WKEDHIYLED KSYKLGDFDV SYASHIPVQF VTDQSSVPVK EINLQKKDHN
  1441  DLENKNCEVC GSEIKCHSCV HLQSEVDQPQ VSYKEADLQK EEHVVMEEKT DQPSDSEMMY
  1501  DSDVPFQIVV NQFPGSVKET HLPKVVLVDL VPGDSDYEVI SDDIPLQLVT DPPQLTVKDI
  1561  SCINTECIDI EDKSCDFFGS EVRCNCKAST PSMTNQCKET FKIINRKKDY IILGEPSCQS
  1621  CGSEMNFNVD ASDQSMTYES QGPDEKMVKY IDSEDKSCGY NGSKGKFNLE DTSHRTTHRL
  1681  QKAHKEASLR KDPRNAGLKG KSCQSSASAV DFGASSKSAL HRRADKKKRS KLKHRDLEVS
  1741  CEPDGFEMNF QCAPPLPSDT DQPQETVKKR HPCKKVSSDL KEKNHDSQSS SVLKVDSVRN
  1801  LKKAKDVIED NPDEPVLEAL PHVPPSFVGK TWSQIMREDD IKINALVKEF REGRFHCYFD
  1861  DDCETKKVSS KGKKKVTWAD LQGKEDTAPT QAVSESDDIV CGISDIDDLS VALDKPCHRH
  1921  PPAERPPKQK GRVASQCQTA KISHSTQTSC KNYPVMKRKI IRQEEDPPKS KCSRLQDDRK
  1981  TKKKVKIGTV EFPASCTKVL KPMQPKALVC VLSSLNIKLK EGEGLPFPKM RHHSWDNDIR
  2041  FICKYKRNIF DYYEPLIKQI VISPPLSVIV PEFERRNWVK IHFNRSNQNS SAGDNDADGQ
  2101  GSASAPLMAV PARYGFNSHQ GTSDSSLFLE ESKVLHAREL PKKRNFQLTF LNHDVVKISP
  2161  KSVRNKLLES QSKKKIHGKR VTTSSNKLGF PKKVYKPIIL QQKPRKASEK QSIWIRTKPS
  2221  DIIRKYISKY SVFLRHRYQS RSAFLGRYLK KKKSVVSRLK KAKRTAKVLL NSSVPPAGAE
  2281  ELSSAMANPP PKRPVRASCR VARRRKKTDE SYHGRQKGPS TPVRAYDLRS SSCLQQRERM
  2341  MTRLANKLRG NEVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZDBF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
8.9 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 8.9 nTPM
  • cerebellum: 8.1 nTPM
  • pituitary gland: 7.6 nTPM
  • basal ganglia: 5.4 nTPM
  • retina: 5.1 nTPM
  • pancreas: 4.7 nTPM

Single-cell type

  • choroid plexus epithelial cells: 414 nCPM
  • brain inhibitory neurons: 117 nCPM
  • other brain neurons: 92 nCPM
  • brain excitatory neurons: 87 nCPM
  • ependymal cells: 52 nCPM
  • podocytes: 45 nCPM

Immune cell

  • T-reg: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • choroid plexus: 22 nTPM
  • hypothalamus: 13 nTPM
  • basal ganglia: 12 nTPM
  • cerebellum: 12 nTPM
  • cerebral cortex: 9.4 nTPM
  • hippocampal formation: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.01
gnomAD missense Z
0.46
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZDBF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZDBF2 as an antibody target. Whether an autoantibody or antibody against ZDBF2 could matter depends on whether native ZDBF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZDBF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZDBF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZDBF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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