FAM83E
Protein FAM83E
Also known as: FA83E_HUMAN, FLJ20200
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q2M2I3
- Gene
- FAM83E
- Ensembl
- ENSG00000105523
- Chromosome
- 19
- Canonical length
- 478 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles,Cytosol
OverviewNCBI Gene
Enables protein kinase binding activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
478 residues, UniProt reviewed canonical sequence.
>Q2M2I3|FAM83E
1 MAASQLAALE GVDSGPRVPG ASPGFLYSEG QRLALEALLS KGAEAFQTCV QREELWPFLS
61 ADEVQGLAAA AEDWTVAKQE PSGMAEGATT TDVDAGSLSY WPGQSEQPAP VLRLGWPVDS
121 AWKGITRAQL YTQPPGEGQP PLKELVRLEI QAAHKLVAVV MDVFTDPDLL LDLVDAATRR
181 WVPVYLLLDR QQLPAFLELA QQLGVNPWNT ENVDVRVVRG CSFQSRWRRQ VSGTVREKFV
241 LLDGERVISG SYSFTWSDAR LHRGLVTLLT GEIVDAFSLE FRTLYAASCP LPPAPPQKPS
301 VIGGLQRGRS PHRVSRRRSV APASPPPPDG PLAHRLAACR VSPATPGPAL SDILRSVQRA
361 RTPSGPPARP SRSMWDLSRL SQLSGSSDGD NELKKSWGSK DTPAKALMRQ RGTGGGPWGE
421 VDSRPPWGGA LPLPPAHRLR YLSPARRRFG GDATFKLQEP RGVRPSDWAP RAGLGGQPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM83E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 35 nTPM
Expression across tissuesHPA
Tissue
- stomach: 35 nTPM
- colon: 31 nTPM
- salivary gland: 29 nTPM
- duodenum: 28 nTPM
- small intestine: 28 nTPM
- rectum: 16 nTPM
Single-cell type
- goblet cells: 269 nCPM
- foveolar cells: 253 nCPM
- colonocytes: 126 nCPM
- tuft cells: 81 nCPM
- neuroendocrine cells: 73 nCPM
- enteric stem cells: 72 nCPM
Immune cell
- basophil: 0.9 nTPM
- neutrophil: 0.6 nTPM
- memory B-cell: 0.4 nTPM
- eosinophil: 0.2 nTPM
- naive CD8 T-cell: 0.2 nTPM
- classical monocyte: 0.1 nTPM
Brain region
- cerebellum: 3 nTPM
- cerebral cortex: 2.4 nTPM
- white matter: 2.4 nTPM
- basal ganglia: 1.9 nTPM
- hippocampal formation: 1.9 nTPM
- hypothalamus: 1.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.61
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.24
- DepMap mean gene effect
- -0.21
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FAM83E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM83E as an antibody target. Whether an autoantibody or antibody against FAM83E could matter depends on whether native FAM83E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM83E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM83E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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