Seroatlas · Human Serome Atlas

SNX24

Sorting nexin-24

Also known as: SBBI31, SNX24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y343
Gene: SNX24
Ensembl: ENSG00000064652
Chromosome: 5
Canonical length: 169 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in protein transport. Predicted to be located in cytoplasmic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>Q9Y343|SNX24
     1  MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK KCIKTPEIPS
    61  KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL NVRHLPSLPK AESCGSFDET
   121  ESEESSKLSH QPVLLFLRDP YVLPAASDFP NVVIEGVLHG IFYPHLQPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 48 nTPM
esophagus: 36 nTPM
parathyroid gland: 24 nTPM
placenta: 24 nTPM
midbrain: 21 nTPM
kidney: 19 nTPM

Single-cell type

esophageal apical cells: 720 nCPM
kupffer cells: 269 nCPM
cardiomyocytes: 251 nCPM
alveolar cells type 1: 239 nCPM
renal collecting duct intercalated cells: 216 nCPM
renal connecting tubule cells: 191 nCPM

Immune cell

non-classical monocyte: 3.2 nTPM
intermediate monocyte: 2.8 nTPM
classical monocyte: 1.4 nTPM
T-reg: 1.4 nTPM
NK-cell: 1.3 nTPM
myeloid DC: 0.7 nTPM

Brain region

white matter: 41 nTPM
medulla oblongata: 32 nTPM
cerebellum: 31 nTPM
pons: 29 nTPM
thalamus: 27 nTPM
spinal cord: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.32
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein transport

Molecular functions

Cellular components

cytoplasmic vesicle membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX24 as an antibody target. Whether an autoantibody or antibody against SNX24 could matter depends on whether native SNX24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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