Seroatlas · Human Serome Atlas

FAM83D

Protein FAM83D

Also known as: C20orf129, CHICA, dJ616B8.3, FA83D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H4H8
Gene
FAM83D
Ensembl
ENSG00000101447
Chromosome
20
Canonical length
585 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Microtubules,Cytokinetic bridge,Mitotic spindle,Cytosol

OverviewNCBI Gene

Enables kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Located in cytosol; intercellular bridge; and mitotic spindle pole. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q9H4H8|FAM83D
     1  MALLSEGLDE VPAACLSPCG PPNPTELFSE SRRLALEELV AGGPEAFAAF LRRERLARFL
    61  NPDEVHAILR AAERPGEEGA AAAAAAEDSF GSSHDCSSGT YFPEQSDLEP PLLELGWPAF
   121  YQGAYRGATR VETHFQPRGA GEGGPYGCKD ALRQQLRSAR EVIAVVMDVF TDIDIFRDLQ
   181  EICRKQGVAV YILLDQALLS QFLDMCMDLK VHPEQEKLMT VRTITGNIYY ARSGTKIIGK
   241  VHEKFTLIDG IRVATGSYSF TWTDGKLNSS NLVILSGQVV EHFDLEFRIL YAQSKPISPK
   301  LLSHFQSSNK FDHLTNRKPQ SKELTLGNLL RMRLARLSST PRKADLDPEM PAEGKAERKP
   361  HDCESSTVSE EDYFSSHRDE LQSRKAIDAA TQTEPGEEMP GLSVSEVGTQ TSITTACAGT
   421  QTAVITRIAS SQTTIWSRST TTQTDMDENI LFPRGTQSTE GSPVSKMSVS RSSSLKSSSS
   481  VSSQGSVASS TGSPASIRTT DFHNPGYPKY LGTPHLELYL SDSLRNLNKE RQFHFAGIRS
   541  RLNHMLAMLS RRTLFTENHL GLHSGNFSRV NLLAVRDVAL YPSYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM83D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • smooth muscle: 89 nTPM
  • esophagus: 82 nTPM
  • colon: 77 nTPM
  • stomach: 42 nTPM
  • small intestine: 34 nTPM
  • bone marrow: 22 nTPM

Single-cell type

  • esophageal apical cells: 561 nCPM
  • syncytiotrophoblasts: 261 nCPM
  • extravillous trophoblasts: 97 nCPM
  • erythrocyte progenitors: 78 nCPM
  • esophageal basal cells: 78 nCPM
  • migrating cytotrophoblasts: 69 nCPM

Immune cell

  • T-reg: 2 nTPM
  • naive CD8 T-cell: 1.4 nTPM
  • memory CD8 T-cell: 1.1 nTPM
  • naive B-cell: 1.1 nTPM
  • naive CD4 T-cell: 1.1 nTPM
  • NK-cell: 1.1 nTPM

Brain region

  • basal ganglia: 4.3 nTPM
  • cerebral cortex: 3.7 nTPM
  • cerebellum: 2.8 nTPM
  • white matter: 2.8 nTPM
  • hippocampal formation: 2.1 nTPM
  • hypothalamus: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
gnomAD missense Z
0.21
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM83D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM83D as an antibody target. Whether an autoantibody or antibody against FAM83D could matter depends on whether native FAM83D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM83D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM83D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FAM83D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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