Seroatlas · Human Serome Atlas

CSNK1D

Casein kinase I isoform delta

Also known as: CKID, CKIdelta, HCKID, KC1D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48730
Gene
CSNK1D
Ensembl
ENSG00000141551
Chromosome
17
Canonical length
415 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Actin filaments,Primary cilium,Cytosol,Principal piece,End piece

OverviewNCBI Gene

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>P48730|CSNK1D
     1  MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ
    61  GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
   121  SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
   181  SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
   241  CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
   301  ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV
   361  SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI PGRVASSGLQ SVVHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 82 nTPM
  • testis: 56 nTPM
  • adrenal gland: 54 nTPM
  • spleen: 54 nTPM
  • colon: 53 nTPM
  • pituitary gland: 53 nTPM

Single-cell type

  • late spermatids: 1,359 nCPM
  • neutrophils: 605 nCPM
  • early spermatids: 371 nCPM
  • esophageal apical cells: 219 nCPM
  • mast cells: 168 nCPM
  • syncytiotrophoblasts: 150 nCPM

Immune cell

  • neutrophil: 31 nTPM
  • eosinophil: 15 nTPM
  • non-classical monocyte: 12 nTPM
  • intermediate monocyte: 11 nTPM
  • classical monocyte: 11 nTPM
  • gdT-cell: 11 nTPM

Brain region

  • hypothalamus: 63 nTPM
  • hippocampal formation: 58 nTPM
  • amygdala: 55 nTPM
  • thalamus: 55 nTPM
  • midbrain: 54 nTPM
  • spinal cord: 54 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CSNK1D.

Disease | AllUniProt

Conditions CSNK1D is implicated in, by any mechanism.

  • Advanced sleep phase syndrome, familial, 2 (FASPS2) MIM:615224

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 57 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Advanced sleep phase syndrome 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
2.7
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSNK1D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK1D as an antibody target. Whether an autoantibody or antibody against CSNK1D could matter depends on whether native CSNK1D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK1D is annotated at the cell surface, where native CSNK1D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CSNK1D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSNK1D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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