Seroatlas · Human Serome Atlas

FAM83F

Protein FAM83F

Also known as: FA83F_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEG4
Gene: FAM83F
Ensembl: ENSG00000133477
Chromosome: 22
Canonical length: 500 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q8NEG4|FAM83F
     1  MAESQLNCLD EAHVNEKVTE AQAAFYYCER RRAALEALLG GGEQAYRERL KEEQLRDFLS
    61  SPERQALRAA WSPYEDAVPA ANARGKSKAK AKAPAPAPAE SGESLAYWPD RSDTEVPPLD
   121  LGWTDTGFYR GVSRVTLFTH PPKDEKAPHL KQVVRQMIQQ AQKVIAVVMD LFTDGDIFQD
   181  IVDAACKRRV PVYIILDEAG VKYFLEMCQD LQLTDFRIRN IRVRSVTGVG FYMPMGRIKG
   241  TLSSRFLMVD GDKVATGSYR FTWSSSHVDR NLLLLLTGQN VEPFDTEFRE LYAISEEVDL
   301  YRQLSLAGRV GLHYSSTVAR KLINPKYALV SGCRHPPGEM MRWAARQQRE AGGNPEGQEE
   361  GASGGESAWR LESFLKDLVT VEQVLPPVEP IPLGELSQKD GRMVSHMHRD LKPKSREAPS
   421  RNGMGEAARG EAAPARRFSS RLFSRRAKRP AAPNGMASSV STETSEVEFL TGKRPNENSS
   481  ADISGKTSPS SAKPSNCVIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM83F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

testis: 39 nTPM
esophagus: 19 nTPM
skin: 17 nTPM
pancreas: 13 nTPM
prostate: 8.4 nTPM
salivary gland: 7.6 nTPM

Single-cell type

late spermatids: 116 nCPM
basal keratinocytes: 88 nCPM
renal collecting duct principal cells: 81 nCPM
breast lactating cells: 71 nCPM
ocular epithelial cells: 69 nCPM
suprabasal keratinocytes: 59 nCPM

Immune cell

basophil: 0.6 nTPM
neutrophil: 0.4 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 2 nTPM
hypothalamus: 1.9 nTPM
white matter: 1.9 nTPM
cerebral cortex: 1.7 nTPM
amygdala: 1.6 nTPM
hippocampal formation: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 1.07
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM83F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM83F as an antibody target. Whether an autoantibody or antibody against FAM83F could matter depends on whether native FAM83F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM83F is annotated at the cell surface, where native FAM83F is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FAM83F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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