Seroatlas · Human Serome Atlas

FAM83A

Protein FAM83A

Also known as: BJ-TSA-9, FA83A_HUMAN, MGC14128

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UY5
Gene: FAM83A
Ensembl: ENSG00000147689
Chromosome: 8
Canonical length: 434 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and protein kinase binding activity. Involved in cell population proliferation and epidermal growth factor receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q86UY5|FAM83A
     1  MSRSRHLGKI RKRLEDVKSQ WVRPARADFS DNESARLATD ALLDGGSEAY WRVLSQEGEV
    61  DFLSSVEAQY IQAQAREPPC PPDTLGGAEA GPKGLDSSSL QSGTYFPVAS EGSEPALLHS
   121  WASAEKPYLK EKSSATVYFQ TVKHNNIRDL VRRCITRTSQ VLVILMDVFT DVEIFCDILE
   181  AANKRGVFVC VLLDQGGVKL FQEMCDKVQI SDSHLKNISI RSVEGEIYCA KSGRKFAGQI
   241  REKFIISDWR FVLSGSYSFT WLCGHVHRNI LSKFTGQAVE LFDEEFRHLY ASSKPVMGLK
   301  SPRLVAPVPP GAAPANGRLS SSSGSASDRT SSNPFSGRSA GSHPGTRSVS ASSGPCSPAA
   361  PHPPPPPRFQ PHQGPWGAPS PQAHLSPRPH DGPPAAVYSN LGAYRPTRLQ LEQLGLVPRL
   421  TPTWRPFLQA SPHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM83A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

esophagus: 60 nTPM
vagina: 8.9 nTPM
cervix: 7.9 nTPM
tonsil: 6.4 nTPM
skin: 6.1 nTPM
seminal vesicle: 5.3 nTPM

Single-cell type

esophageal apical cells: 1,359 nCPM
ocular epithelial cells: 644 nCPM
esophageal suprabasal cells: 238 nCPM
esophageal basal cells: 94 nCPM
breast lactating cells: 52 nCPM
respiratory secretory cells: 45 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.2 nTPM
cerebral cortex: 1 nTPM
choroid plexus: 1 nTPM
amygdala: 0.9 nTPM
basal ganglia: 0.8 nTPM
hippocampal formation: 0.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FAM83A.

Disease | ImmuneIEDB

Conditions an epitope on FAM83A was assayed in.

invasive ductal carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM83A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM83A as an antibody target. Whether an autoantibody or antibody against FAM83A could matter depends on whether native FAM83A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM83A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM83A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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