Seroatlas · Human Serome Atlas

SEC13

Protein SEC13 homolog

Also known as: D3S1231E, npp-20, SEC13_HUMAN, SEC13L1, SEC13R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55735
Gene
SEC13
Ensembl
ENSG00000157020
Chromosome
3
Canonical length
322 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>P55735|SEC13
     1  MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV
    61  WQVAWAHPMY GNILASCSYD RKVIIWREEN GTWEKSHEHA GHDSSVNSVC WAPHDYGLIL
   121  ACGSSDGAIS LLTYTGEGQW EVKKINNAHT IGCNAVSWAP AVVPGSLIDH PSGQKPNYIK
   181  RFASGGCDNL IKLWKEEEDG QWKEEQKLEA HSDWVRDVAW APSIGLPTST IASCSQDGRV
   241  FIWTCDDASS NTWSPKLLHK FNDVVWHVSW SITANILAVS GGDNKVTLWK ESVDGQWVCI
   301  SDVNKGQGSV SASVTEGQQN EQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
112 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 112 nTPM
  • pituitary gland: 111 nTPM
  • duodenum: 108 nTPM
  • choroid plexus: 98 nTPM
  • liver: 92 nTPM
  • small intestine: 91 nTPM

Single-cell type

  • extravillous trophoblasts: 248 nCPM
  • syncytiotrophoblasts: 212 nCPM
  • enterocytes: 191 nCPM
  • esophageal apical cells: 168 nCPM
  • myonuclei: 162 nCPM
  • cytotrophoblasts: 158 nCPM

Immune cell

  • myeloid DC: 223 nTPM
  • plasmacytoid DC: 199 nTPM
  • total PBMC: 177 nTPM
  • classical monocyte: 163 nTPM
  • intermediate monocyte: 145 nTPM
  • basophil: 128 nTPM

Brain region

  • choroid plexus: 51 nTPM
  • white matter: 47 nTPM
  • hypothalamus: 47 nTPM
  • cerebellum: 44 nTPM
  • basal ganglia: 43 nTPM
  • pons: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.02
gnomAD missense Z
0.62
DepMap mean gene effect
-1.49
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC13 as an antibody target. Whether an autoantibody or antibody against SEC13 could matter depends on whether native SEC13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SEC13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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