Seroatlas · Human Serome Atlas

FAM83B

Protein FAM83B

Also known as: C6orf143, FA83B_HUMAN, FLJ30642

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T0W9
Gene: FAM83B
Ensembl: ENSG00000168143
Chromosome: 6
Canonical length: 1011 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables epidermal growth factor receptor binding activity; phosphatidylinositol 3-kinase binding activity; and protein kinase binding activity. Involved in cell population proliferation and positive regulation of epidermal growth factor receptor signaling pathway. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1011 residues, UniProt reviewed canonical sequence.

>Q5T0W9|FAM83B
     1  METSSMLSSL NDECKSDNYI EPHYKEWYRV AIDILIEHGL EAYQEFLVQE RVSDFLAEEE
    61  INYILKNVQK VAQSTAHGTD DSCDDTLSSG TYWPVESDVE APNLDLGWPY VMPGLLGGTH
   121  IDLLFHPPRA HLLTIKETIR KMIKEARKVI ALVMDIFTDV DIFKEIVEAS TRGVSVYILL
   181  DESNFNHFLN MTEKQGCSVQ RLRNIRVRTV KGQDYLSKTG AKFHGKMEQK FLLVDCQKVM
   241  YGSYSYMWSF EKAHLSMVQI ITGQLVESFD EEFRTLYARS CVPSSFAQEE SARVKHGKAL
   301  WENGTYQHSV SSLASVSSQR NLFGRQDKIH KLDSSYFKNR GIYTLNEHDK YNIRSHGYKP
   361  HFVPNFNGPN AIRQFQPNQI NENWKRHSYA GEQPETVPYL LLNRALNRTN NPPGNWKKPS
   421  DSLSVASSSR EGYVSHHNTP AQSFANRLAQ RKTTNLADRN SNVRRSFNGT DNHIRFLQQR
   481  MPTLEHTTKS FLRNWRIESY LNDHSEATPD SNGSALGDRF EGYDNPENLK ANALYTHSRL
   541  RSSLVFKPTL PEQKEVNSCT TGSSNSTIIG SQGSETPKEV PDTPTNVQHL TDKPLPESIP
   601  KLPLQSEAPK MHTLQVPENH SVALNQTTNG HTESNNYIYK TLGVNKQTEN LKNQQTENLL
   661  KRRSFPLFDN SKANLDPGNS KHYVYSTLTR NRVRQPEKPK EDLLKSSKSM HNVTHNLEED
   721  EEEVTKRNSP SGTTTKSVSI AALLDVNKEE SNKELASKKE VKGSPSFLKK GSQKLRSLLS
   781  LTPDKKENLS KNKAPAFYRL CSSSDTLVSE GEENQKPKKS DTKVDSSPRR KHSSSSNSQG
   841  SIHKSKEDVT VSPSQEINAP PDENKRTPSP GPVESKFLER AGDASAPRFN TEQIQYRDSR
   901  EINAVVTPER RPTSSPRPTS SELLRSHSTD RRVYSRFEPF CKIESSIQPT SNMPNTSINR
   961  PEIKSATMGN SYGRSSPLLN YNTGVYRSYQ PNENKFRGFM QKFGNFIHKN K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM83B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

skin: 24 nTPM
esophagus: 12 nTPM
vagina: 8.1 nTPM
rectum: 7.7 nTPM
colon: 7.5 nTPM
duodenum: 7 nTPM

Single-cell type

suprabasal keratinocytes: 352 nCPM
ocular epithelial cells: 352 nCPM
basal keratinocytes: 259 nCPM
urothelial cells: 253 nCPM
esophageal suprabasal cells: 146 nCPM
esophageal basal cells: 128 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

midbrain: 2.2 nTPM
basal ganglia: 0.9 nTPM
cerebellum: 0.9 nTPM
white matter: 0.9 nTPM
amygdala: 0.8 nTPM
cerebral cortex: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM83B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM83B as an antibody target. Whether an autoantibody or antibody against FAM83B could matter depends on whether native FAM83B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM83B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM83B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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