Seroatlas · Human Serome Atlas

PBXIP1

Pre-B-cell leukemia transcription factor-interacting protein 1

Also known as: HPIP, PBIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AQ6
Gene: PBXIP1
Ensembl: ENSG00000163346
Chromosome: 1
Canonical length: 731 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

731 residues, UniProt reviewed canonical sequence.

>Q96AQ6|PBXIP1
     1  MASCPDSDNS WVLAGSESLP VETLGPASRM DPESERALQA PHSPSKTDGK ELAGTMDGEG
    61  TLFQTESPQS GSILTEETEV KGTLEGDVCG VEPPGPGDTV VQGDLQETTV VTGLGPDTQD
   121  LEGQSPPQSL PSTPKAAWIR EEGRCSSSDD DTDVDMEGLR RRRGREAGPP QPMVPLAVEN
   181  QAGGEGAGGE LGISLNMCLL GALVLLGLGV LLFSGGLSES ETGPMEEVER QVLPDPEVLE
   241  AVGDRQDGLR EQLQAPVPPD SVPSLQNMGL LLDKLAKENQ DIRLLQAQLQ AQKEELQSLM
   301  HQPKGLEEEN AQLRGALQQG EAFQRALESE LQQLRARLQG LEADCVRGPD GVCLSGGRGP
   361  QGDKAIREQG PREQEPELSF LKQKEQLEAE AQALRQELER QRRLLGSVQQ DLERSLQDAS
   421  RGDPAHAGLA ELGHRLAQKL QGLENWGQDP GVSANASKAW HQKSHFQNSR EWSGKEKWWD
   481  GQRDRKAEHW KHKKEESGRE RKKNWGGQED REPAGRWKEG RPRVEESGSK KEGKRQGPKE
   541  PPRKSGSFHS SGEKQKQPRW REGTKDSHDP LPSWAELLRP KYRAPQGCSG VDECARQEGL
   601  TFFGTELAPV RQQELASLLR TYLARLPWAG QLTKELPLSP AFFGEDGIFR HDRLRFRDFV
   661  DALEDSLEEV AVQQTGDDDE VDDFEDFIFS HFFGDKALKK RSGKKDKHSQ SPRAAGPREG
   721  HSHSHHHHHR G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PBXIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 672 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 672 nTPM
basal ganglia: 175 nTPM
pituitary gland: 162 nTPM
blood vessel: 145 nTPM
midbrain: 135 nTPM
skeletal muscle: 131 nTPM

Single-cell type

tuft cells: 415 nCPM
late spermatids: 281 nCPM
müller glia: 221 nCPM
smooth muscle cells: 170 nCPM
early spermatids: 160 nCPM
t-cells: 135 nCPM

Immune cell

T-reg: 198 nTPM
eosinophil: 184 nTPM
basophil: 130 nTPM
MAIT T-cell: 117 nTPM
memory CD4 T-cell: 113 nTPM
neutrophil: 95 nTPM

Brain region

choroid plexus: 431 nTPM
thalamus: 255 nTPM
medulla oblongata: 250 nTPM
midbrain: 206 nTPM
basal ganglia: 185 nTPM
hypothalamus: 176 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

articular cartilage development
cell adhesion
cell migration
extracellular matrix disassembly
hemopoiesis
negative regulation of DNA-templated transcription
positive regulation of chondrocyte proliferation
positive regulation of Wnt signaling pathway
production of molecular mediator involved in inflammatory response
regulation of DNA-templated transcription
gene expression involved in extracellular matrix organization

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cell Cycle Progression and Pre-B-cell Leukemia Transcription Factor-Interacting

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PBXIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PBXIP1 as an antibody target. Whether an autoantibody or antibody against PBXIP1 could matter depends on whether native PBXIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PBXIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PBXIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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