Cyclin/Cyclin-like subunit Ssn8
IPR043198
Definition
Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) PMID:12910258. This entry represents several Cyclin families (C, L, Q, T1, T2, and H/Ccl1) and yeast RNA polymerase II holoenzyme cyclin-like subunit (also known as Ssn8/Srb11). Cyclin C can regulate both cell cycle progression and gene transcription. The Cdk8-cyclin C complex is a component of the RNA polymerase II holoenzyme PMID:10993082. Cyclin L is a transcriptional regulator involved in the regulation of RNA polymerase II transcription and participating in regulating the pre-mRNA splicing process [[cite:PMID:11980906], [cite:PMID:17494991]]. Cyclin Q (also known as Cyclin M) consists of cyclin-related protein FAM58A PMID:24218572. Cyclin-T2 is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex PMID:10364329. Cyclin-H from vertebrates, mcs2 from fission yeast and Ccl1 from budding yeasts are cyclins that play a role in cell cycle PMID:16769902. Cyclin-T associates with CDK9 which are subunits of the positive-transcription elongation factor (P-TEFb) PMID:10574912. Ssn8/Srb11 is a component of the SRB8-11 complex (consists of SRB8, SSN2/SRB9, SSN3/SRB10 and SSN8/SRB11), which is a regulatory module of the mediator complex that is involved in regulation of basal and activated RNA polymerase II-dependent transcription [[cite:PMID:7877695], [cite:PMID:9702190]].
8 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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