Nucleotidyltransferase superfamily
IPR043519
Definition
This entry represents the Pol beta-like nucleotidyltransferase (NT) superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. The following functional groups of nucleotidyltransferases have been included in this superfamily PMID:10075991: PolyA polymerases Protein nucleotidyltransferases, such as GlnD and GlnE CCA-adding enzyme Interferon-induced 2'-5' synthetase DNA polymerase beta and terminal deoxynucleotidyltransferase Antibiotic nucleotidyltransferases
25 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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