Seroatlas · Human Serome Atlas

TENT4A

Terminal nucleotidyltransferase 4A

Also known as: LAK-1, PAPD7, PAPD7_HUMAN, POLK, POLS, TRF4, TRF4-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5XG87
Gene: TENT4A
Ensembl: ENSG00000112941
Chromosome: 5
Canonical length: 792 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

792 residues, UniProt reviewed canonical sequence.

>Q5XG87|TENT4A
     1  MDPRVAWIQP EQKGPANALW MQIWETSQGV GRGGSGFASY FCLNSPALDT AAAAGAAGRG
    61  SGGLGPALPA ASPPPPGPTA PAALPPALLT ALGPAAEGAR RLHKSPSLSS SSSSSSSNAE
   121  SGTESPGCSS SSSSSASLGR PGGGRGGAFF NFADGAPSAP GTANGHPGPR GPAPAGSPSQ
   181  HQFHPGRRKR ENKASTYGLN YLLSGSRAAA LSGGGGPGAQ APRPGTPWKS RAYSPGIQGL
   241  HEEIIDFYNF MSPCPEEAAM RREVVKRIET VVKDLWPTAD VQIFGSFSTG LYLPTSDIDL
   301  VVFGKWERPP LQLLEQALRK HNVAEPCSIK VLDKATVPII KLTDQETEVK VDISFNMETG
   361  VRAAEFIKNY MKKYSLLPYL ILVLKQFLLQ RDLNEVFTGG ISSYSLILMA ISFLQLHPRI
   421  DARRADENLG MLLVEFFELY GRNFNYLKTG IRIKEGGAYI AKEEIMKAMT SGYRPSMLCI
   481  EDPLLPGNDV GRSSYGAMQV KQVFDYAYIV LSHAVSPLAR SYPNRDAEST LGRIIKVTQE
   541  VIDYRRWIKE KWGSKAHPSP GMDSRIKIKE RIATCNGEQT QNREPESPYG QRLTLSLSSP
   601  QLLSSGSSAS SVSSLSGSDV DSDTPPCTTP SVYQFSLQAP APLMAGLPTA LPMPSGKPQP
   661  TTSRTLIMTT NNQTRFTIPP PTLGVAPVPC RQAGVEGTAS LKAVHHMSSP AIPSASPNPL
   721  SSPHLYHKQH NGMKLSMKGS HGHTQGGGYS SVGSGGVRPP VGNRGHHQYN RTGWRRKKHT
   781  HTRDSLPVSL SR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TENT4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 26 nTPM
liver: 21 nTPM
cerebellum: 20 nTPM
skin: 16 nTPM
ovary: 15 nTPM
spleen: 14 nTPM

Single-cell type

pdcs: 116 nCPM
cone photoreceptor cells: 93 nCPM
plasma cells: 88 nCPM
gonadotrophs: 86 nCPM
adipocytes: 85 nCPM
salivary myoepithelial cells: 84 nCPM

Immune cell

plasmacytoid DC: 1.1 nTPM
gdT-cell: 0.6 nTPM
MAIT T-cell: 0.6 nTPM
T-reg: 0.6 nTPM
memory B-cell: 0.5 nTPM
naive CD4 T-cell: 0.5 nTPM

Brain region

cerebellum: 39 nTPM
cerebral cortex: 25 nTPM
hippocampal formation: 23 nTPM
white matter: 23 nTPM
basal ganglia: 22 nTPM
hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TENT4A as an antibody target. Whether an autoantibody or antibody against TENT4A could matter depends on whether native TENT4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TENT4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TENT4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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