Seroatlas · Human Serome Atlas

OAS2

2'-5'-oligoadenylate synthase 2

Also known as: OAS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P29728
Gene
OAS2
Ensembl
ENSG00000111335
Chromosome
12
Canonical length
719 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Centrosome
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

719 residues, UniProt reviewed canonical sequence.

>P29728|OAS2
     1  MGNGESQLSS VPAQKLGWFI QEYLKPYEEC QTLIDEMVNT ICDVLQEPEQ FPLVQGVAIG
    61  GSYGRKTVLR GNSDGTLVLF FSDLKQFQDQ KRSQRDILDK TGDKLKFCLF TKWLKNNFEI
   121  QKSLDGFTIQ VFTKNQRISF EVLAAFNALS LNDNPSPWIY RELKRSLDKT NASPGEFAVC
   181  FTELQQKFFD NRPGKLKDLI LLIKHWHQQC QKKIKDLPSL SPYALELLTV YAWEQGCRKD
   241  NFDIAEGVRT VLELIKCQEK LCIYWMVNYN FEDETIRNIL LHQLQSARPV ILDPVDPTNN
   301  VSGDKICWQW LKKEAQTWLT SPNLDNELPA PSWNVLPAPL FTTPGHLLDK FIKEFLQPNK
   361  CFLEQIDSAV NIIRTFLKEN CFRQSTAKIQ IVRGGSTAKG TALKTGSDAD LVVFHNSLKS
   421  YTSQKNERHK IVKEIHEQLK AFWREKEEEL EVSFEPPKWK APRVLSFSLK SKVLNESVSF
   481  DVLPAFNALG QLSSGSTPSP EVYAGLIDLY KSSDLPGGEF STCFTVLQRN FIRSRPTKLK
   541  DLIRLVKHWY KECERKLKPK GSLPPKYALE LLTIYAWEQG SGVPDFDTAE GFRTVLELVT
   601  QYQQLCIFWK VNYNFEDETV RKFLLSQLQK TRPVILDPAE PTGDVGGGDR WCWHLLAKEA
   661  KEWLSSPCFK DGTGNPIPPW KVPTMQTPGS CGARIHPIVN EMFSSRSHRI LNNNSKRNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OAS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 63 nTPM
  • spleen: 41 nTPM
  • lymph node: 36 nTPM
  • thymus: 34 nTPM
  • tonsil: 31 nTPM
  • lung: 25 nTPM

Single-cell type

  • kupffer cells: 34 nCPM
  • esophageal apical cells: 32 nCPM
  • vascular endothelial cells: 23 nCPM
  • monocytes: 23 nCPM
  • plasma cells: 22 nCPM
  • foveolar cells: 20 nCPM

Immune cell

  • non-classical monocyte: 61 nTPM
  • intermediate monocyte: 56 nTPM
  • classical monocyte: 36 nTPM
  • T-reg: 36 nTPM
  • MAIT T-cell: 34 nTPM
  • NK-cell: 32 nTPM

Brain region

  • spinal cord: 21 nTPM
  • medulla oblongata: 19 nTPM
  • pons: 13 nTPM
  • white matter: 9.5 nTPM
  • midbrain: 9.1 nTPM
  • thalamus: 8.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OAS2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 125 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autoinflammation and autoimmunity with immune dysregulation 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OAS2 as an antibody target. Whether an autoantibody or antibody against OAS2 could matter depends on whether native OAS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OAS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OAS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OAS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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