PAPOLB

Protein identityUniProt · HPA

UniProt accession

Q9NRJ5

Gene

PAPOLB

Ensembl

ENSG00000218823

Chromosome

7

Canonical length

637 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing and mRNA processing. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

637 residues, UniProt reviewed canonical sequence.

>Q9NRJ5|PAPOLB
     1  MMPFPVTTQG PPQPAPPPNR YGVSSPISLA VPKETDCLLT QRLIETLRPF GVFEEEEELQ
    61  RRILVLEKLN NLVKEWIREI SESKSLPQSV IENVGGKIFT FGSYRLGVHT KGADIDALCV
   121  APSHVDRSDF FTSFYAKLKL QEEVKDLRAV EEAFVPVIKL CFDGIEIDIL FARLALQTIP
   181  EDLDLRDDSL LKNLDIRCIR SLNGCRVTDE ILHLVPNIDN FRLTLRAIKL WAKCHNIYSN
   241  ILGFLGGVSW AMLVARTCQL YPNAVASTLV RKFFLVFSEW EWPNPVLLKE PEERNLNLPV
   301  WDPRVNPSDR YHLMPIITPA YPQQNSTYNV SISTRMVMIE EFKQGLAITH EILLSKAEWS
   361  KLFEAPSFFQ KYKHYIVLLA SASTEKQHLE WVGLVESKIR ILVGSLEKNE FITLAHVNPQ
   421  SFPAPKENPD MEEFRTMWVI GLGLKKPDNS EILSIDLTYD IQSFTDTVYR QAVNSKMFEM
   481  GMKITAMHLR RKELHQLLPH HVLQDKKAHS TEGRRLTDLN DSSFDLSAGC ENSMSVPSST
   541  STMKTGPLIS SSQGRNSPAL AVMTASVANI QATEFSLQQV NTNESSGVAL NESIPHAVSQ
   601  PAISPSPKAM VARVVSSTCL ISHPDLQETQ QQTYLIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PAPOLB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

28 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.81

gnomAD pLI

0

gnomAD missense Z

-0.15

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mRNA processing
• RNA 3'-end processing

Molecular functions

• ATP binding
• metal ion binding
• poly(A) RNA polymerase activity
• RNA binding

Cellular components

• endoplasmic reticulum
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Poly(A) polymerase, RNA-binding domain
• Poly(A) polymerase, central domain
• Nucleotidyltransferase, class I-like, C-terminal
• Poly(A) polymerase
• Nucleotidyltransferase superfamily
• Poly(A) polymerase, nucleotidyltransferase domain
• Poly(A) polymerase predicted RNA binding domain
• Poly(A) polymerase central domain
• Poly(A) polymerase nucleotidyltransferase domain

KeywordsUniProt

• ATP-binding
• Magnesium
• Manganese
• Metal-binding
• mRNA processing
• Nucleotide-binding
• Nucleus
• RNA-binding
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PAPOLB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GSG1