Seroatlas · Human Serome Atlas

ZFR2

Zinc finger RNA-binding protein 2

Also known as: KIAA1086, ZFR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UPR6
Gene: ZFR2
Ensembl: ENSG00000105278
Chromosome: 19
Canonical length: 939 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

939 residues, UniProt reviewed canonical sequence.

>Q9UPR6|ZFR2
     1  MATSQYFDFA QGGGPQYSAQ PPTLPLPTVG ASYTAQPTPG MDPAVNPAFP PAAPAGYGGY
    61  QPHSGQDFAY GSRPQEPVPT ATTMATYQDS YSYGQSAAAR SYEDRPYFQS AALQSGRMTA
   121  ADSGQPGTQE ACGQPSPHGS HSHAQPPQQA PIVESGQPAS TLSSGYTYPT ATGVQPESSA
   181  SIVTSYPPPS YNPTCTAYTA PSYPNYDASV YSAASPFYPP AQPPPPPGPP QQLPPPPAPA
   241  GSGSSPRADS KPPLPSKLPR PKAGPRQLQL HYCDICKISC AGPQTYREHL GGQKHRKKEA
   301  AQKTGVQPNG SPRGVQAQLH CDLCAVSCTG ADAYAAHIRG SKHQKVFKLH AKLGKPIPTL
   361  EPALATESPP GAEAKPTSPT GPSVCASSRP ALAKRPVASK ALCEGPPEPQ AAGCRPQWGK
   421  PAQPKLEGPG APTQGGSKEA PAGCSDAQPV GPEYVEEVFS DEGRVLRFHC KLCECSFNDL
   481  NAKDLHVRGR RHRLQYRKKV NPDLPIATEP SSRARKVLEE RMRKQRHLAE ERLEQLRRWH
   541  AERRRLEEEP PQDVPPHAPP DWAQPLLMGR PESPASAPLQ PGRRPASSDD RHVMCKHATI
   601  YPTEQELLAV QRAVSHAERA LKLVSDTLAE EDRGRREEEG DKRSSVAPQT RVLKGVMRVG
   661  ILAKGLLLRG DRNVRLALLC SEKPTHSLLR RIAQQLPRQL QMVTEDEYEV SSDPEANIVI
   721  SSCEEPRMQV TISVTSPLMR EDPSTDPGVE EPQADAGDVL SPKKCLESLA ALRHARWFQA
   781  RASGLQPCVI VIRVLRDLCR RVPTWGALPA WAMELLVEKA VSSAAGPLGP GDAVRRVLEC
   841  VATGTLLTDG PGLQDPCERD QTDALEPMTL QEREDVTASA QHALRMLAFR QTHKVLGMDL
   901  LPPRHRLGAR FRKRQRGPGE GEEGAGEKKR GRRGGEGLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 27 nTPM
hypothalamus: 15 nTPM
cerebral cortex: 14 nTPM
testis: 14 nTPM
basal ganglia: 12 nTPM
retina: 10 nTPM

Single-cell type

retinal amacrine cells: 149 nCPM
thyrotrophs: 139 nCPM
lactotrophs: 130 nCPM
retinal horizontal cells: 108 nCPM
retinal bipolar cells: 105 nCPM
rod photoreceptor cells: 92 nCPM

Immune cell

MAIT T-cell: 1.2 nTPM
gdT-cell: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM
basophil: 1 nTPM
naive CD8 T-cell: 0.9 nTPM
memory CD4 T-cell: 0.7 nTPM

Brain region

hypothalamus: 37 nTPM
cerebral cortex: 34 nTPM
basal ganglia: 34 nTPM
amygdala: 29 nTPM
hippocampal formation: 25 nTPM
white matter: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFR2 as an antibody target. Whether an autoantibody or antibody against ZFR2 could matter depends on whether native ZFR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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