OAS3

Protein identityUniProt · HPA

UniProt accession

Q9Y6K5

Gene

OAS3

Ensembl

ENSG00000111331

Chromosome

12

Canonical length

1087 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1087 residues, UniProt reviewed canonical sequence.

>Q9Y6K5|OAS3
     1  MDLYSTPAAA LDRFVARRLQ PRKEFVEKAR RALGALAAAL RERGGRLGAA APRVLKTVKG
    61  GSSGRGTALK GGCDSELVIF LDCFKSYVDQ RARRAEILSE MRASLESWWQ NPVPGLRLTF
   121  PEQSVPGALQ FRLTSVDLED WMDVSLVPAF NVLGQAGSGV KPKPQVYSTL LNSGCQGGEH
   181  AACFTELRRN FVNIRPAKLK NLILLVKHWY HQVCLQGLWK ETLPPVYALE LLTIFAWEQG
   241  CKKDAFSLAE GLRTVLGLIQ QHQHLCVFWT VNYGFEDPAV GQFLQRQLKR PRPVILDPAD
   301  PTWDLGNGAA WHWDLLAQEA ASCYDHPCFL RGMGDPVQSW KGPGLPRAGC SGLGHPIQLD
   361  PNQKTPENSK SLNAVYPRAG SKPPSCPAPG PTGAASIVPS VPGMALDLSQ IPTKELDRFI
   421  QDHLKPSPQF QEQVKKAIDI ILRCLHENCV HKASRVSKGG SFGRGTDLRD GCDVELIIFL
   481  NCFTDYKDQG PRRAEILDEM RAQLESWWQD QVPSLSLQFP EQNVPEALQF QLVSTALKSW
   541  TDVSLLPAFD AVGQLSSGTK PNPQVYSRLL TSGCQEGEHK ACFAELRRNF MNIRPVKLKN
   601  LILLVKHWYR QVAAQNKGKG PAPASLPPAY ALELLTIFAW EQGCRQDCFN MAQGFRTVLG
   661  LVQQHQQLCV YWTVNYSTED PAMRMHLLGQ LRKPRPLVLD PADPTWNVGH GSWELLAQEA
   721  AALGMQACFL SRDGTSVQPW DVMPALLYQT PAGDLDKFIS EFLQPNRQFL AQVNKAVDTI
   781  CSFLKENCFR NSPIKVIKVV KGGSSAKGTA LRGRSDADLV VFLSCFSQFT EQGNKRAEII
   841  SEIRAQLEAC QQERQFEVKF EVSKWENPRV LSFSLTSQTM LDQSVDFDVL PAFDALGQLV
   901  SGSRPSSQVY VDLIHSYSNA GEYSTCFTEL QRDFIISRPT KLKSLIRLVK HWYQQCTKIS
   961  KGRGSLPPQH GLELLTVYAW EQGGKDSQFN MAEGFRTVLE LVTQYRQLCI YWTINYNAKD
  1021  KTVGDFLKQQ LQKPRPIILD PADPTGNLGH NARWDLLAKE AAACTSALCC MGRNGIPIQP
  1081  WPVKAAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OAS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

26 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OAS3.

Disease | ImmuneIEDB

Conditions an epitope on OAS3 was assayed in.

• type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.27

gnomAD pLI

0

gnomAD missense Z

0.26

DepMap mean gene effect

-0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antiviral innate immune response
• cellular response to exogenous dsRNA
• defense response to bacterium
• defense response to virus
• interleukin-27-mediated signaling pathway
• MDA-5 signaling pathway
• negative regulation of chemokine (C-C motif) ligand 5 production
• negative regulation of chemokine (C-X-C motif) ligand 2 production
• negative regulation of IP-10 production
• negative regulation of type I interferon-mediated signaling pathway
• negative regulation of viral genome replication
• nucleobase-containing compound metabolic process
• positive regulation of interferon-beta production
• positive regulation of monocyte chemotactic protein-1 production
• positive regulation of tumor necrosis factor production
• regulation of ribonuclease activity
• response to virus
• RIG-I signaling pathway
• type I interferon-mediated signaling pathway
• negative regulation of chemokine (C-X-C motif) ligand 9 production

Molecular functions

• 2'-5'-oligoadenylate synthetase activity
• ATP binding
• double-stranded RNA binding
• metal ion binding

Cellular components

• cytoplasm
• cytosol
• extracellular space
• intracellular membrane-bounded organelle
• membrane
• nucleoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Polymerase, nucleotidyl transferase domain
• 2-5OAS/ClassI-CCAase, nucleotidyltransferase domain
• 2-5-oligoadenylate synthetase, C-terminal conserved site
• 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
• 2-5-oligoadenylate synthetase, N-terminal conserved site
• Nucleotidyltransferase superfamily
• Nucleotidyltransferase domain
• 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

KeywordsUniProt

• Acetylation
• Antiviral defense
• ATP-binding
• Cytoplasm
• Immunity
• Innate immunity
• Magnesium
• Metal-binding
• Nucleotide-binding
• Nucleotidyltransferase
• Nucleus
• Phosphoprotein
• Repeat
• RNA-binding
• Transferase

InteractionsUniProt · HPA

Protein binding partners of OAS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DHX30
• EIF6
• FTSJ3
• IFRD2
• MAVS