Seroatlas · Human Serome Atlas

POLL

DNA polymerase lambda

Also known as: DPOLL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UGP5
Gene
POLL
Ensembl
ENSG00000166169
Chromosome
10
Canonical length
575 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q9UGP5|POLL
     1  MDPRGILKAF PKRQKIHADA SSKVLAKIPR REEGEEAEEW LSSLRAHVVR TGIGRARAEL
    61  FEKQIVQHGG QLCPAQGPGV THIVVDEGMD YERALRLLRL PQLPPGAQLV KSAWLSLCLQ
   121  ERRLVDVAGF SIFIPSRYLD HPQPSKAEQD ASIPPGTHEA LLQTALSPPP PPTRPVSPPQ
   181  KAKEAPNTQA QPISDDEASD GEETQVSAAD LEALISGHYP TSLEGDCEPS PAPAVLDKWV
   241  CAQPSSQKAT NHNLHITEKL EVLAKAYSVQ GDKWRALGYA KAINALKSFH KPVTSYQEAC
   301  SIPGIGKRMA EKIIEILESG HLRKLDHISE SVPVLELFSN IWGAGTKTAQ MWYQQGFRSL
   361  EDIRSQASLT TQQAIGLKHY SDFLERMPRE EATEIEQTVQ KAAQAFNSGL LCVACGSYRR
   421  GKATCGDVDV LITHPDGRSH RGIFSRLLDS LRQEGFLTDD LVSQEENGQQ QKYLGVCRLP
   481  GPGRRHRRLD IIVVPYSEFA CALLYFTGSA HFNRSMRALA KTKGMSLSEH ALSTAVVRNT
   541  HGCKVGPGRV LPTPTEKDVF RLLGLPYREP AERDW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 43 nTPM
  • testis: 39 nTPM
  • skeletal muscle: 32 nTPM
  • pituitary gland: 27 nTPM
  • stomach: 26 nTPM
  • liver: 26 nTPM

Single-cell type

  • late spermatids: 85 nCPM
  • late primary spermatocytes: 71 nCPM
  • proximal tubule cells: 31 nCPM
  • choroid plexus epithelial cells: 29 nCPM
  • pancreatic acinar cells: 28 nCPM
  • lactotrophs: 26 nCPM

Immune cell

  • naive CD4 T-cell: 12 nTPM
  • myeloid DC: 12 nTPM
  • MAIT T-cell: 11 nTPM
  • T-reg: 10 nTPM
  • NK-cell: 9.5 nTPM
  • classical monocyte: 9.2 nTPM

Brain region

  • choroid plexus: 31 nTPM
  • cerebral cortex: 30 nTPM
  • basal ganglia: 30 nTPM
  • hippocampal formation: 29 nTPM
  • pons: 29 nTPM
  • white matter: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.55
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLL as an antibody target. Whether an autoantibody or antibody against POLL could matter depends on whether native POLL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POLL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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