Seroatlas · Human Serome Atlas

POLB

DNA polymerase beta

Also known as: DPOLB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P06746
Gene: POLB
Ensembl: ENSG00000070501
Chromosome: 8
Canonical length: 335 aa
Protein class: Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>P06746|POLB
     1  MSKRKAPQET LNGGITDMLT ELANFEKNVS QAIHKYNAYR KAASVIAKYP HKIKSGAEAK
    61  KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL TRVSGIGPSA ARKFVDEGIK
   121  TLEDLRKNED KLNHHQRIGL KYFGDFEKRI PREEMLQMQD IVLNEVKKVD SEYIATVCGS
   181  FRRGAESSGD MDVLLTHPSF TSESTKQPKL LHQVVEQLQK VHFITDTLSK GETKFMGVCQ
   241  LPSKNDEKEY PHRRIDIRLI PKDQYYCGVL YFTGSDIFNK NMRAHALEKG FTINEYTIRP
   301  LGVTGVAGEP LPVDSEKDIF DYIQWKYREP KDRSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POLB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 176 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 176 nTPM
skeletal muscle: 80 nTPM
tongue: 65 nTPM
testis: 50 nTPM
bone marrow: 48 nTPM
liver: 32 nTPM

Single-cell type

pdcs: 517 nCPM
early spermatids: 316 nCPM
late spermatids: 226 nCPM
late primary spermatocytes: 138 nCPM
myonuclei: 105 nCPM
microglia: 84 nCPM

Immune cell

plasmacytoid DC: 85 nTPM
neutrophil: 64 nTPM
eosinophil: 48 nTPM
basophil: 48 nTPM
non-classical monocyte: 26 nTPM
NK-cell: 22 nTPM

Brain region

cerebellum: 134 nTPM
hypothalamus: 25 nTPM
pons: 22 nTPM
white matter: 22 nTPM
cerebral cortex: 21 nTPM
spinal cord: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 1.57
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POLB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POLB as an antibody target. Whether an autoantibody or antibody against POLB could matter depends on whether native POLB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POLB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POLB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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