TENT4B

Protein identityUniProt · HPA

UniProt accession

Q8NDF8

Gene

TENT4B

Ensembl

ENSG00000121274

Chromosome

16

Canonical length

572 aa

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoli,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables guanylyltransferase activity; poly(A) RNA polymerase activity; and telomerase RNA binding activity. Involved in RNA metabolic process; carbohydrate homeostasis; and regulation of nucleobase-containing compound metabolic process. Located in cytosol; nucleolus; and plasma membrane. Part of TRAMP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>Q8NDF8|TENT4B
     1  MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
    61  AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
   121  HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
   181  VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
   241  VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
   301  DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
   361  EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
   421  VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
   481  RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
   541  TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TENT4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

6.7 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.21

gnomAD pLI

1

DepMap mean gene effect

-0.2

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• carbohydrate homeostasis
• cell division
• histone mRNA catabolic process
• miRNA catabolic process
• mRNA 3'-end processing
• negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
• negative regulation of telomere maintenance via telomerase
• poly(A)-dependent snoRNA 3'-end processing
• polyadenylation-dependent ncRNA catabolic process
• positive regulation of 3'-UTR-mediated mRNA stabilization
• RNA 3'-end processing
• RNA catabolic process
• rRNA processing

Molecular functions

• adenylyltransferase activity
• ATP binding
• guanylyltransferase activity
• metal ion binding
• poly(A) RNA polymerase activity
• RNA binding
• telomerase RNA binding

Cellular components

• cytoplasm
• cytosol
• nucleolus
• plasma membrane
• TRAMP complex

Protein domainsUniProt · Pfam · InterPro

• PAP/25A-associated
• Nucleotidyltransferase superfamily
• Nucleotidyltransferase Trf4-like
• Poly(A) RNA polymerase, mitochondrial-like, central palm domain
• Cid1 family poly A polymerase
• Poly(A) RNA polymerase, mitochondrial-like, central palm domain

KeywordsUniProt

• ATP-binding
• Cell cycle
• Cell division
• Cytoplasm
• Isopeptide bond
• Magnesium
• Manganese
• Metal-binding
• Mitosis
• mRNA processing
• Nucleotide-binding
• Nucleotidyltransferase
• Nucleus
• Phosphoprotein
• RNA-binding
• rRNA processing
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of TENT4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CPEB1