Seroatlas · Human Serome Atlas

MALSU1

Mitochondrial assembly of ribosomal large subunit protein 1

Also known as: C7orf30, MASU1_HUMAN, mtRsfA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EH3
Gene: MALSU1
Ensembl: ENSG00000156928
Chromosome: 7
Canonical length: 234 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables mitochondrial large ribosomal subunit binding activity. Involved in negative regulation of mitochondrial translation and ribosomal large subunit biogenesis. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q96EH3|MALSU1
     1  MGPGGRVARL LAPLMWRRAV SSVAGSAVGA EPGLRLLAVQ RLPVGAAFCR ACQTPNFVRG
    61  LHSEPGLEER AEGTVNEGRP ESDAADHTGP KFDIDMMVSL LRQENARDIC VIQVPPEMRY
   121  TDYFVIVSGT STRHLHAMAF YVVKMYKHLK CKRDPHVKIE GKDTDDWLCV DFGSMVIHLM
   181  LPETREIYEL EKLWTLRSYD DQLAQIAPET VPEDFILGIE DDTSSVTPVE LKCE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MALSU1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 7 nTPM
tongue: 5.9 nTPM
skeletal muscle: 5.6 nTPM
liver: 5.2 nTPM
heart muscle: 4.6 nTPM
testis: 4.3 nTPM

Single-cell type

oocytes: 295 nCPM
early spermatids: 235 nCPM
retinal pigment epithelial cells: 222 nCPM
esophageal suprabasal cells: 133 nCPM
esophageal apical cells: 126 nCPM
late primary spermatocytes: 125 nCPM

Immune cell

naive CD4 T-cell: 1.4 nTPM
memory CD4 T-cell: 1.2 nTPM
T-reg: 1.2 nTPM
classical monocyte: 1 nTPM
MAIT T-cell: 1 nTPM
memory B-cell: 1 nTPM

Brain region

choroid plexus: 6.1 nTPM
cerebellum: 5 nTPM
cerebral cortex: 4.5 nTPM
white matter: 4.4 nTPM
basal ganglia: 4.1 nTPM
hypothalamus: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -1.21
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial large ribosomal subunit assembly
negative regulation of translation
ribosomal large subunit biogenesis
negative regulation of mitochondrial translation
negative regulation of ribosome biogenesis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleotidyltransferase superfamily
Protein Iojap/ribosomal silencing factor RsfS
Ribosomal silencing factor during starvation

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MALSU1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MALSU1 as an antibody target. Whether an autoantibody or antibody against MALSU1 could matter depends on whether native MALSU1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MALSU1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MALSU1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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