Serpin superfamily, domain 1
IPR042178
Definition
Serpins (SERine Proteinase INhibitors) belong to MEROPS inhibitor family I4, clan ID. Most serpin family members are indeed serine protease inhibitors, but several have additional cross-class inhibition functions and inhibit cysteine protease family members such as the caspases and cathepsins [[cite:PMID:8034697], [cite:PMID:7851535]]. Others, such as ovalbumin, are incapable of protease inhibition and serve other functions PMID:8417965. This superfamily represents the first domain found in Serpin proteins.
38 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (38 proteins: gene, accession, name)
- AGT
- HMSD
- SERPINA1
- SERPINA10
- SERPINA11
- SERPINA12
- SERPINA13P
- SERPINA2
- SERPINA3
- SERPINA4
- SERPINA5
- SERPINA6
- SERPINA7
- SERPINA9
- SERPINB1
- SERPINB10
- SERPINB11
- SERPINB12
- SERPINB13
- SERPINB2
- SERPINB3
- SERPINB4
- SERPINB5
- SERPINB6
- SERPINB7
- SERPINB8
- SERPINB9
- SERPINC1
- SERPIND1
- SERPINE1
- SERPINE2
- SERPINE3
- SERPINF1
- SERPINF2
- SERPING1
- SERPINH1
- SERPINI1
- SERPINI2
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