Seroatlas · Human Serome Atlas

SERPINA5

Plasma serine protease inhibitor

Also known as: IPSP_HUMAN, PAI3, PCI, PLANH3, PROCI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05154
Gene
SERPINA5
Ensembl
ENSG00000188488
Chromosome
14
Canonical length
406 aa
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>P05154|SERPINA5
     1  MQLFLLLCLV LLSPQGASLH RHHPREMKKR VEDLHVGATV APSSRRDFTF DLYRALASAA
    61  PSQSIFFSPV SISMSLAMLS LGAGSSTKMQ ILEGLGLNLQ KSSEKELHRG FQQLLQELNQ
   121  PRDGFQLSLG NALFTDLVVD LQDTFVSAMK TLYLADTFPT NFRDSAGAMK QINDYVAKQT
   181  KGKIVDLLKN LDSNAVVIMV NYIFFKAKWE TSFNHKGTQE QDFYVTSETV VRVPMMSRED
   241  QYHYLLDRNL SCRVVGVPYQ GNATALFILP SEGKMQQVEN GLSEKTLRKW LKMFKKRQLE
   301  LYLPKFSIEG SYQLEKVLPS LGISNVFTSH ADLSGISNHS NIQVSEMVHK AVVEVDESGT
   361  RAAAATGTIF TFRSARLNSQ RLVFNRPFLM FIVDNNILFL GKVNRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
735 nTPM

Expression across tissuesHPA

Tissue

  • liver: 735 nTPM
  • adrenal gland: 461 nTPM
  • testis: 405 nTPM
  • pancreas: 164 nTPM
  • gallbladder: 151 nTPM
  • seminal vesicle: 145 nTPM

Single-cell type

  • late spermatids: 84 nCPM
  • early spermatids: 52 nCPM
  • endometrial luminal cells: 32 nCPM
  • pancreatic duct cells: 18 nCPM
  • cholangiocytes: 16 nCPM
  • hepatocytes: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 15 nTPM
  • medulla oblongata: 10 nTPM
  • pons: 8.4 nTPM
  • midbrain: 7.4 nTPM
  • white matter: 6.1 nTPM
  • choroid plexus: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.72
gnomAD pLI
0
gnomAD missense Z
-1.24
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERPINA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINA5 as an antibody target. Whether an autoantibody or antibody against SERPINA5 could matter depends on whether native SERPINA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINA5 is annotated at the cell surface, where native SERPINA5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SERPINA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SERPINA5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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