Seroatlas · Human Serome Atlas

SERPINB1

Leukocyte elastase inhibitor

Also known as: EI, ELANH2, ILEU_HUMAN, LEI, MNEI, PI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P30740
Gene
SERPINB1
Ensembl
ENSG00000021355
Chromosome
6
Canonical length
379 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Cytoplasmic bodies
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

379 residues, UniProt reviewed canonical sequence.

>P30740|SERPINB1
     1  MEQLSSANTR FALDLFLALS ENNPAGNIFI SPFSISSAMA MVFLGTRGNT AAQLSKTFHF
    61  NTVEEVHSRF QSLNADINKR GASYILKLAN RLYGEKTYNF LPEFLVSTQK TYGADLASVD
   121  FQHASEDARK TINQWVKGQT EGKIPELLAS GMVDNMTKLV LVNAIYFKGN WKDKFMKEAT
   181  TNAPFRLNKK DRKTVKMMYQ KKKFAYGYIE DLKCRVLELP YQGEELSMVI LLPDDIEDES
   241  TGLKKIEEQL TLEKLHEWTK PENLDFIEVN VSLPRFKLEE SYTLNSDLAR LGVQDLFNSS
   301  KADLSGMSGA RDIFISKIVH KSFVEVNEEG TEAAAATAGI ATFCMLMPEE NFTADHPFLF
   361  FIRHNSSGSI LFLGRFSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
498 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 498 nTPM
  • bone marrow: 441 nTPM
  • pancreas: 238 nTPM
  • duodenum: 132 nTPM
  • vagina: 116 nTPM
  • tonsil: 115 nTPM

Single-cell type

  • esophageal apical cells: 10,957 nCPM
  • esophageal suprabasal cells: 3,641 nCPM
  • pancreatic acinar cells: 2,079 nCPM
  • neutrophils: 1,392 nCPM
  • neutrophil progenitors: 1,115 nCPM
  • monocyte progenitors: 792 nCPM

Immune cell

  • classical monocyte: 207 nTPM
  • neutrophil: 183 nTPM
  • total PBMC: 175 nTPM
  • myeloid DC: 150 nTPM
  • basophil: 118 nTPM
  • eosinophil: 110 nTPM

Brain region

  • choroid plexus: 27 nTPM
  • medulla oblongata: 23 nTPM
  • white matter: 21 nTPM
  • cerebral cortex: 21 nTPM
  • basal ganglia: 20 nTPM
  • thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
0.79
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERPINB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINB1 as an antibody target. Whether an autoantibody or antibody against SERPINB1 could matter depends on whether native SERPINB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINB1 is annotated as secreted, so native SERPINB1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SERPINB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SERPINB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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