Seroatlas · Human Serome Atlas

SERPINB12

Serpin B12

Also known as: SPB12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96P63
Gene
SERPINB12
Ensembl
ENSG00000166634
Chromosome
18
Canonical length
405 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Enables serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of protein catabolic process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

405 residues, UniProt reviewed canonical sequence.

>Q96P63|SERPINB12
     1  MDSLVTANTK FCFDLFQEIG KDDRHKNIFF SPLSLSAALG MVRLGARSDS AHQIDEVLHF
    61  NEFSQNESKE PDPCLKSNKQ KAGSLNNESG LVSCYFGQLL SKLDRIKTDY TLSIANRLYG
   121  EQEFPICQEY LDGVIQFYHT TIESVDFQKN PEKSRQEINF WVECQSQGKI KELFSKDAIN
   181  AETVLVLVNA VYFKAKWETY FDHENTVDAP FCLNANENKS VKMMTQKGLY RIGFIEEVKA
   241  QILEMRYTKG KLSMFVLLPS HSKDNLKGLE ELERKITYEK MVAWSSSENM SEESVVLSFP
   301  RFTLEDSYDL NSILQDMGIT DIFDETRADL TGISPSPNLY LSKIIHKTFV EVDENGTQAA
   361  AATGAVVSER SLRSWVEFNA NHPFLFFIRH NKTQTILFYG RVCSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINB12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • skin: 56 nTPM
  • vagina: 37 nTPM
  • cervix: 24 nTPM
  • esophagus: 8.8 nTPM
  • thymus: 3.2 nTPM
  • breast: 3.1 nTPM

Single-cell type

  • esophageal apical cells: 15 nCPM
  • suprabasal keratinocytes: 5.2 nCPM
  • syncytiotrophoblasts: 3.3 nCPM
  • esophageal suprabasal cells: 2 nCPM
  • late primary spermatocytes: 1.6 nCPM
  • lacrimal acinar cells: 0.9 nCPM

Immune cell

  • basophil: 0.2 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 2.3 nTPM
  • choroid plexus: 1.9 nTPM
  • basal ganglia: 1.8 nTPM
  • cerebral cortex: 1.8 nTPM
  • thalamus: 1.8 nTPM
  • white matter: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SERPINB12.

Disease | ImmuneIEDB

Conditions an epitope on SERPINB12 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.96
gnomAD pLI
0
gnomAD missense Z
-0.71
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERPINB12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINB12 as an antibody target. Whether an autoantibody or antibody against SERPINB12 could matter depends on whether native SERPINB12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINB12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERPINB12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SERPINB12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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