Seroatlas · Human Serome Atlas

HMSD

Serpin-like protein HMSD

Also known as: ACC-6, ACC6, C18orf53, HMSD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MTL9
Gene: HMSD
Ensembl: ENSG00000221887
Chromosome: 18
Canonical length: 139 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a serpin-domain containing protein that may function as a serine protease inhibitor. This gene is primarily expressed in cells of myeloid lineage. A polymorphism in this gene may result in the expression a splice variant that encodes a minor histocompatibility antigen. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

139 residues, UniProt reviewed canonical sequence.

>A8MTL9|HMSD
     1  MSISSALAMV FMGAKGNTAA QMSQALCFSK IGGEDGDIHR GFQSLLVAIN RTDTEYVLRT
    61  ANGLFGEKSY DFLTGFTDSC GKFYQATIKQ LDFVNDTEKS TTRVNSWVAD KTKGENILLF
   121  YFDNILNSFI VSSLQNCQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HMSD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 31 nTPM
midbrain: 9.7 nTPM
hippocampal formation: 5 nTPM
hypothalamus: 4.9 nTPM
amygdala: 2.8 nTPM
basal ganglia: 2.5 nTPM

Single-cell type

epicardial cells: 39 nCPM
alveolar cells type 1: 15 nCPM
pdcs: 12 nCPM
oligodendrocytes: 9.4 nCPM
esophageal basal cells: 8.9 nCPM
undifferentiated spermatogonia: 8.3 nCPM

Immune cell

plasmacytoid DC: 1.8 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 11 nTPM
medulla oblongata: 9.7 nTPM
pons: 8.1 nTPM
cerebellum: 5.5 nTPM
spinal cord: 5.1 nTPM
thalamus: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0.01
gnomAD missense Z: 0.58
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HMSD as an antibody target. Whether an autoantibody or antibody against HMSD could matter depends on whether native HMSD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HMSD is annotated as secreted, so native HMSD circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HMSD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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