SERPINB10
Serpin B10
Also known as: PI10, SPB10_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P48595
- Gene
- SERPINB10
- Ensembl
- ENSG00000242550
- Chromosome
- 18
- Canonical length
- 397 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. [provided by RefSeq, Dec 2015]
Canonical amino-acid sequenceUniProt
397 residues, UniProt reviewed canonical sequence.
>P48595|SERPINB10
1 MDSLATSINQ FALELSKKLA ESAQGKNIFF SSWSISTSLT IVYLGAKGTT AAQMAQVLQF
61 NRDQGVKCDP ESEKKRKMEF NLSNSEEIHS DFQTLISEIL KPNDDYLLKT ANAIYGEKTY
121 AFHNKYLEDM KTYFGAEPQP VNFVEASDQI RKDINSWVER QTEGKIQNLL PDDSVDSTTR
181 MILVNALYFK GIWEHQFLVQ NTTEKPFRIN ETTSKPVQMM FMKKKLHIFH IEKPKAVGLQ
241 LYYKSRDLSL LILLPEDING LEQLEKAITY EKLNEWTSAD MMELYEVQLH LPKFKLEDSY
301 DLKSTLSSMG MSDAFSQSKA DFSGMSSARN LFLSNVFHKA FVEINEQGTE AAAGSGSEID
361 IRIRVPSIEF NANHPFLFFI RHNKTNTILF YGRLCSPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SERPINB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.24
- Highest tissue expression
- 63 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 63 nTPM
- thymus: 0.8 nTPM
- skin: 0.7 nTPM
- spleen: 0.6 nTPM
- esophagus: 0.4 nTPM
- tonsil: 0.3 nTPM
Single-cell type
- neutrophil progenitors: 132 nCPM
- monocyte progenitors: 32 nCPM
- neutrophils: 9.2 nCPM
- endometrial secretory cells: 5.5 nCPM
- monocytes: 4.8 nCPM
- respiratory deuterosomal cells: 4.1 nCPM
Immune cell
- eosinophil: 1 nTPM
- classical monocyte: 0.6 nTPM
- plasmacytoid DC: 0.6 nTPM
- neutrophil: 0.3 nTPM
- total PBMC: 0.2 nTPM
- myeloid DC: 0.1 nTPM
Brain region
- cerebellum: 3.2 nTPM
- cerebral cortex: 2.8 nTPM
- hypothalamus: 2.6 nTPM
- white matter: 2.6 nTPM
- hippocampal formation: 2.5 nTPM
- basal ganglia: 2.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.47
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.97
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SERPINB10 as an antibody target. Whether an autoantibody or antibody against SERPINB10 could matter depends on whether native SERPINB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SERPINB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SERPINB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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