Seroatlas · Human Serome Atlas

SERPINB11

Serpin B11

Also known as: SPB11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96P15
Gene: SERPINB11
Ensembl: ENSG00000206072
Chromosome: 18
Canonical length: 392 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>Q96P15|SERPINB11
     1  MGSLSTANVE FCLDVFKELN SNNIGDNIFF SSLSLLYALS MVLLGARGET EEQLEKVLHF
    61  SHTVDSLKPG FKDSPKCSQA GRIHSEFGVE FSQINQPDSN CTLSIANRLY GTKTMAFHQQ
   121  YLSCSEKWYQ ARLQTVDFEQ STEETRKTIN AWVENKTNGK VANLFGKSTI DPSSVMVLVN
   181  AIYFKGQWQN KFQVRETVKS PFQLSEGKNV TVEMMYQIGT FKLAFVKEPQ MQVLELPYVN
   241  NKLSMIILLP VGIANLKQIE KQLNSGTFHE WTSSSNMMER EVEVHLPRFK LETKYELNSL
   301  LKSLGVTDLF NQVKADLSGM SPTKGLYLSK AIHKSYLDVS EEGTEAAAAT GDSIAVKSLP
   361  MRAQFKANHP FLFFIRHTHT NTILFCGKLA SP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINB11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

prostate: 31 nTPM
esophagus: 26 nTPM
salivary gland: 8.9 nTPM
tonsil: 8.5 nTPM
vagina: 7 nTPM
cervix: 3.5 nTPM

Single-cell type

conjunctival goblet cells: 656 nCPM
respiratory secretory cells: 214 nCPM
esophageal apical cells: 206 nCPM
prostatic club cells: 151 nCPM
prostatic glandular cells: 72 nCPM
respiratory deuterosomal cells: 64 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.8 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.16
gnomAD pLI: 0
gnomAD missense Z: -1.02

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINB11 as an antibody target. Whether an autoantibody or antibody against SERPINB11 could matter depends on whether native SERPINB11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINB11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERPINB11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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