Seroatlas · Human Serome Atlas

SERPINE3

Serpin E3

Also known as: SERP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MV23
Gene: SERPINE3
Ensembl: ENSG00000253309
Chromosome: 13
Canonical length: 424 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>A8MV23|SERPINE3
     1  MPPFLITLFL FHSCCLRANG HLREGMTLLK TEFALHLYQS VAACRNETNF VISPAGVSLP
    61  LEILQFGAEG STGQQLADAL GYTVHDKRVK DFLHAVYATL PTSSQGTEME LACSLFVQVG
   121  TPLSPCFVEH VSWWANSSLE PADLSEPNST AIQTSEGASR ETAGGGPSEG PGGWPWEQVS
   181  AAFAQLVLVS TMSFQGTWRK RFSSTDTQIL PFTCAYGLVL QVPMMHQTTE VNYGQFQDTA
   241  GHQVGVLELP YLGSAVSLFL VLPRDKDTPL SHIEPHLTAS TIHLWTTSLR RARMDVFLPR
   301  FRIQNQFNLK SILNSWGVTD LFDPLKANLK GISGQDGFYV SEAIHKAKIE VLEEGTKASG
   361  ATALLLLKRS RIPIFKADRP FIYFLREPNT GITVFFDRIQ IIYQCLSSNK GSFVHYPLKN
   421  KHSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

retina: 1.7 nTPM
pancreas: 1.2 nTPM
skin: 0.8 nTPM
adipose tissue: 0.7 nTPM
small intestine: 0.6 nTPM
cerebellum: 0.4 nTPM

Single-cell type

epicardial cells: 275 nCPM
epididymal basal cells: 120 nCPM
pdcs: 103 nCPM
breast secretory cells: 45 nCPM
retinal bipolar cells: 31 nCPM
breast hormone-responsive cells: 31 nCPM

Immune cell

intermediate monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 6.3 nTPM
cerebral cortex: 5 nTPM
hippocampal formation: 4.3 nTPM
white matter: 4.3 nTPM
pons: 4.1 nTPM
medulla oblongata: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINE3 as an antibody target. Whether an autoantibody or antibody against SERPINE3 could matter depends on whether native SERPINE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINE3 is annotated as secreted, so native SERPINE3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SERPINE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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