Seroatlas · Human Serome Atlas

SERPINA2

Alpha-1-antitrypsin-related protein

Also known as: A1ATR_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P20848
Gene: SERPINA2
Canonical length: 421 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SERPINA2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>P20848|SERPINA2
     1  MPFSVSWGIL LLAGLCCLVP SSLVEDPQED AAQKTDTSHH DQGDWEDLAC QKISYNVTDL
    61  AFDLYKELAD LSQTSNVLVT PTSVAMAFAM LSLGTKADTR TEILEGLNVN LTETPEAKIH
   121  ECFQQVLQAL SRPDTRLQLT TGSSLFVNKS MKLVDTFLED TKKLYHSEAS SINFRDTEEA
   181  KEQINNYVEK RTGRKVVDLV KHLKKDTSLA LVDYISFHGK WKDKFKAEHI MVEGFHVDDK
   241  TIIRVPMINH LGRFDIHRDR ELSSWVLAQH YVGNATAFFI LPDPKKMWQL EEKLTYSHLE
   301  NIQRAFDIRS INLHFPKLSI SGTYKLKRVL RNLGITKIFS NEADLSGVSQ EAPLKLSKAV
   361  HVAVLTIDEK GTEATGAPHL EEKAWSKYQT VMFNRPFLVI IKDDITNFPL FIGKVVNPTQ
   421  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 101 nTPM

Expression across tissuesHPA

Tissue

epididymis: 101 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM
breast: 0 nTPM

Single-cell type

epididymal principal cells: 0.1 nCPM
neutrophils: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

non-classical monocyte: 2.2 nTPM
intermediate monocyte: 1.8 nTPM
total PBMC: 1.1 nTPM
neutrophil: 1 nTPM
classical monocyte: 0.8 nTPM
eosinophil: 0.2 nTPM

Brain region

cerebral cortex: 0.4 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

OntologyGO

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERPINA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINA2 as an antibody target. Whether an autoantibody or antibody against SERPINA2 could matter depends on whether native SERPINA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERPINA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...