Seroatlas · Human Serome Atlas

SERPINB8

Serpin B8

Also known as: CAP2, PI8, SPB8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50452
Gene: SERPINB8
Ensembl: ENSG00000166401
Chromosome: 18
Canonical length: 374 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Actin filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>P50452|SERPINB8
     1  MDDLCEANGT FAISLFKILG EEDNSRNVFF SPMSISSALA MVFMGAKGST AAQMSQALCL
    61  YKDGDIHRGF QSLLSEVNRT GTQYLLRTAN RLFGEKTCDF LPDFKEYCQK FYQAELEELS
   121  FAEDTEECRK HINDWVAEKT EGKISEVLDA GTVDPLTKLV LVNAIYFKGK WNEQFDRKYT
   181  RGMLFKTNEE KKTVQMMFKE AKFKMGYADE VHTQVLELPY VEEELSMVIL LPDDNTDLAV
   241  VEKALTYEKF KAWTNSEKLT KSKVQVFLPR LKLEESYDLE PFLRRLGMID AFDEAKADFS
   301  GMSTEKNVPL SKVAHKCFVE VNEEGTEAAA ATAVVRNSRC SRMEPRFCAD HPFLFFIRHH
   361  KTNCILFCGR FSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINB8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

skin: 55 nTPM
liver: 35 nTPM
bone marrow: 29 nTPM
esophagus: 28 nTPM
urinary bladder: 22 nTPM
tonsil: 17 nTPM

Single-cell type

esophageal apical cells: 168 nCPM
monocyte progenitors: 107 nCPM
monocytes: 85 nCPM
esophageal suprabasal cells: 81 nCPM
suprabasal keratinocytes: 57 nCPM
neutrophils: 51 nCPM

Immune cell

myeloid DC: 54 nTPM
classical monocyte: 44 nTPM
intermediate monocyte: 34 nTPM
plasmacytoid DC: 29 nTPM
non-classical monocyte: 18 nTPM
neutrophil: 12 nTPM

Brain region

medulla oblongata: 14 nTPM
thalamus: 13 nTPM
white matter: 12 nTPM
pons: 12 nTPM
spinal cord: 12 nTPM
midbrain: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SERPINB8.

Disease | AllUniProt

Conditions SERPINB8 is implicated in, by any mechanism.

Peeling skin syndrome 5 (PSS5) MIM:617115

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 109 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Peeling skin syndrome 5

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: -0.95
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINB8 as an antibody target. Whether an autoantibody or antibody against SERPINB8 could matter depends on whether native SERPINB8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINB8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERPINB8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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