SERPINB13

Protein identityUniProt · HPA

UniProt accession

Q9UIV8

Gene

SERPINB13

Ensembl

ENSG00000197641

Chromosome

18

Canonical length

391 aa

Protein class

Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nuclear speckles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein inhibits the activity of cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of cancer. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

391 residues, UniProt reviewed canonical sequence.

>Q9UIV8|SERPINB13
     1  MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE
    61  KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY ELNITNRLFG EKTYLFLQKY
   121  LDYVEKYYHA SLEPVDFVNA ADESRKKINS WVESKTNEKI KDLFPDGSIS SSTKLVLVNM
   181  VYFKGQWDRE FKKENTKEEK FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN
   241  DLSMFVLLPN DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL
   301  AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG IGFTVTSAPG
   361  HENVHCNHPF LFFIRHNESN SILFFGRFSS P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINB13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

171 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SERPINB13.

Disease | ImmuneIEDB

Conditions an epitope on SERPINB13 was assayed in.

• hepatocellular carcinoma T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against SERPINB13 are reported. Each links to that disease's full target list.

• Diabetes Mellitus, Type 1 4

ReferencesPubMed · IEDB

Publications for SERPINB13 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.15

gnomAD pLI

0

gnomAD missense Z

-0.54

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of endopeptidase activity
• regulation of proteolysis
• response to UV
• negative regulation of keratinocyte apoptotic process

Molecular functions

• cysteine-type endopeptidase inhibitor activity
• protease binding
• serine-type endopeptidase inhibitor activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• extracellular space
• lysosomal lumen
• nuclear speck
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Serpin family
• Serpin, conserved site
• Serpin domain
• Serpin superfamily
• Serpin superfamily, domain 1
• Serpin superfamily, domain 2
• Serpin (serine protease inhibitor)

KeywordsUniProt

• Cytoplasm
• Protease inhibitor
• Serine protease inhibitor