Seroatlas · Human Serome Atlas

SERPINI2

Serpin I2

Also known as: MEPI, PI14, SPI2_HUMAN, TSA2004

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75830
Gene
SERPINI2
Ensembl
ENSG00000114204
Chromosome
3
Canonical length
405 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to digestive system

OverviewNCBI Gene

The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

405 residues, UniProt reviewed canonical sequence.

>O75830|SERPINI2
     1  MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ
    61  LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK
   121  EQYLHGNKEF FQSAIKLVDF QDAKACAEMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV
   181  NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS
   241  YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD
   301  VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL
   361  AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
1,339 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 1,339 nTPM
  • fallopian tube: 5 nTPM
  • choroid plexus: 2.7 nTPM
  • small intestine: 2.3 nTPM
  • basal ganglia: 1.9 nTPM
  • lung: 1.2 nTPM

Single-cell type

  • pancreatic acinar cells: 623 nCPM
  • ependymal cells: 621 nCPM
  • respiratory ciliated cells: 461 nCPM
  • bergmann glia: 337 nCPM
  • choroid plexus epithelial cells: 244 nCPM
  • astrocytes: 153 nCPM

Immune cell

  • plasmacytoid DC: 0.5 nTPM
  • classical monocyte: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • medulla oblongata: 26 nTPM
  • choroid plexus: 25 nTPM
  • spinal cord: 24 nTPM
  • midbrain: 20 nTPM
  • white matter: 15 nTPM
  • cerebellum: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SERPINI2.

Disease | ImmuneIEDB

Conditions an epitope on SERPINI2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
0.45
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERPINI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINI2 as an antibody target. Whether an autoantibody or antibody against SERPINI2 could matter depends on whether native SERPINI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINI2 is annotated as secreted, so native SERPINI2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SERPINI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SERPINI2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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