Seroatlas · Human Serome Atlas

SERPINA6

Corticosteroid-binding globulin

Also known as: CBG, CBG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P08185
Gene: SERPINA6
Ensembl: ENSG00000170099
Chromosome: 14
Canonical length: 405 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

405 residues, UniProt reviewed canonical sequence.

>P08185|SERPINA6
     1  MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL YKHLVALSPK
    61  KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER SETEIHQGFQ HLHQLFAKSD
   121  TSLEMTMGNA LFLDGSLELL ESFSADIKHY YESEVLAMNF QDWATASRQI NSYVKNKTQG
   181  KIVDLFSGLD SPAILVLVNY IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI
   241  SYLHDSELPC QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY
   301  IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV LQLNEEGVDT
   361  AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR VMNPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 726 nTPM

Expression across tissuesHPA

Tissue

liver: 726 nTPM
kidney: 41 nTPM
gallbladder: 33 nTPM
pancreas: 16 nTPM
fallopian tube: 12 nTPM
breast: 8 nTPM

Single-cell type

cholangiocytes: 47 nCPM
hepatocytes: 47 nCPM
endometrial ciliated cells: 21 nCPM
fallopian tube ciliated cells: 19 nCPM
epididymal efferent duct ciliated cells: 13 nCPM
proximal tubule cells: 10 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 0.3 nTPM
hippocampal formation: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hypothalamus: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SERPINA6.

Disease | AllUniProt

Conditions SERPINA6 is implicated in, by any mechanism.

Corticosteroid-binding globulin deficiency (CBG deficiency) MIM:611489

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 83 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Corticosteroid-binding globulin deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: -0.66
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

glucocorticoid biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINA6 as an antibody target. Whether an autoantibody or antibody against SERPINA6 could matter depends on whether native SERPINA6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINA6 is annotated as secreted, so native SERPINA6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SERPINA6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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