Seroatlas · Human Serome Atlas

SERPINB9

Serpin B9

Also known as: CAP3, PI9, SPB9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P50453
Gene: SERPINB9
Ensembl: ENSG00000170542
Chromosome: 6
Canonical length: 376 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>P50453|SERPINB9
     1  METLSNASGT FAIRLLKILC QDNPSHNVFC SPVSISSALA MVLLGAKGNT ATQMAQALSL
    61  NTEEDIHRAF QSLLTEVNKA GTQYLLRTAN RLFGEKTCQF LSTFKESCLQ FYHAELKELS
   121  FIRAAEESRK HINTWVSKKT EGKIEELLPG SSIDAETRLV LVNAIYFKGK WNEPFDETYT
   181  REMPFKINQE EQRPVQMMYQ EATFKLAHVG EVRAQLLELP YARKELSLLV LLPDDGVELS
   241  TVEKSLTFEK LTAWTKPDCM KSTEVEVLLP KFKLQEDYDM ESVLRHLGIV DAFQQGKADL
   301  SAMSAERDLC LSKFVHKSFV EVNEEGTEAA AASSCFVVAE CCMESGPRFC ADHPFLFFIR
   361  HNRANSILFC GRFSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINB9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

placenta: 49 nTPM
tonsil: 39 nTPM
lymph node: 38 nTPM
appendix: 33 nTPM
spleen: 27 nTPM
lung: 25 nTPM

Single-cell type

cdc: 926 nCPM
monocytes: 691 nCPM
syncytiotrophoblasts: 465 nCPM
retinal ganglion cells: 359 nCPM
macrophages: 357 nCPM
microglia: 302 nCPM

Immune cell

intermediate monocyte: 100 nTPM
non-classical monocyte: 63 nTPM
NK-cell: 51 nTPM
classical monocyte: 48 nTPM
gdT-cell: 43 nTPM
memory CD8 T-cell: 41 nTPM

Brain region

medulla oblongata: 21 nTPM
pons: 20 nTPM
spinal cord: 20 nTPM
hypothalamus: 19 nTPM
midbrain: 19 nTPM
white matter: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0.01
gnomAD missense Z: 0.01
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINB9 as an antibody target. Whether an autoantibody or antibody against SERPINB9 could matter depends on whether native SERPINB9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINB9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERPINB9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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