Seroatlas · Human Serome Atlas

SERPINF1

Pigment epithelium-derived factor

Also known as: EPC-1, PEDF, PEDF_HUMAN, PIG35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36955
Gene
SERPINF1
Ensembl
ENSG00000132386
Chromosome
17
Canonical length
418 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>P36955|SERPINF1
     1  MQALVLLLCI GALLGHSSCQ NPASPPEEGS PDPDSTGALV EEEDPFFKVP VNKLAAAVSN
    61  FGYDLYRVRS STSPTTNVLL SPLSVATALS ALSLGAEQRT ESIIHRALYY DLISSPDIHG
   121  TYKELLDTVT APQKNLKSAS RIVFEKKLRI KSSFVAPLEK SYGTRPRVLT GNPRLDLQEI
   181  NNWVQAQMKG KLARSTKEIP DEISILLLGV AHFKGQWVTK FDSRKTSLED FYLDEERTVR
   241  VPMMSDPKAV LRYGLDSDLS CKIAQLPLTG SMSIIFFLPL KVTQNLTLIE ESLTSEFIHD
   301  IDRELKTVQA VLTVPKLKLS YEGEVTKSLQ EMKLQSLFDS PDFSKITGKP IKLTQVEHRA
   361  GFEWNEDGAG TTPSPGLQPA HLTFPLDYHL NQPFIFVLRD TDTGALLFIG KILDPRGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
4,586 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 4,586 nTPM
  • liver: 911 nTPM
  • adipose tissue: 568 nTPM
  • breast: 537 nTPM
  • gallbladder: 524 nTPM
  • fallopian tube: 505 nTPM

Single-cell type

  • retinal pigment epithelial cells: 4,429 nCPM
  • decidual stromal cells: 3,858 nCPM
  • leydig cells: 1,025 nCPM
  • cytotrophoblasts: 957 nCPM
  • fibroblasts: 933 nCPM
  • peritubular myoid cells: 906 nCPM

Immune cell

  • plasmacytoid DC: 1,458 nTPM
  • myeloid DC: 80 nTPM
  • total PBMC: 14 nTPM
  • classical monocyte: 12 nTPM
  • memory B-cell: 9 nTPM
  • naive CD8 T-cell: 5.6 nTPM

Brain region

  • choroid plexus: 3,986 nTPM
  • hippocampal formation: 198 nTPM
  • thalamus: 75 nTPM
  • cerebral cortex: 56 nTPM
  • cerebellum: 50 nTPM
  • basal ganglia: 39 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SERPINF1.

Disease | AllUniProt

Conditions SERPINF1 is implicated in, by any mechanism.

Disease | GeneticClinVar

62 pathogenic / likely-pathogenic of 427 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
-0.91
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERPINF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINF1 as an antibody target. Whether an autoantibody or antibody against SERPINF1 could matter depends on whether native SERPINF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINF1 is annotated as secreted, so native SERPINF1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SERPINF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SERPINF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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