Seroatlas · Human Serome Atlas

SERPINF2

Alpha-2-antiplasmin

Also known as: A2AP, A2AP_HUMAN, AAP, ALPHA-2-PI, alpha2AP, API, PLI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08697
Gene
SERPINF2
Ensembl
ENSG00000167711
Chromosome
17
Canonical length
491 aa
Protein class
Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>P08697|SERPINF2
     1  MALLWGLLVL SWSCLQGPCS VFSPVSAMEP LGRQLTSGPN QEQVSPLTLL KLGNQEPGGQ
    61  TALKSPPGVC SRDPTPEQTH RLARAMMAFT ADLFSLVAQT STCPNLILSP LSVALALSHL
   121  ALGAQNHTLQ RLQQVLHAGS GPCLPHLLSR LCQDLGPGAF RLAARMYLQK GFPIKEDFLE
   181  QSEQLFGAKP VSLTGKQEDD LANINQWVKE ATEGKIQEFL SGLPEDTVLL LLNAIHFQGF
   241  WRNKFDPSLT QRDSFHLDEQ FTVPVEMMQA RTYPLRWFLL EQPEIQVAHF PFKNNMSFVV
   301  LVPTHFEWNV SQVLANLSWD TLHPPLVWER PTKVRLPKLY LKHQMDLVAT LSQLGLQELF
   361  QAPDLRGISE QSLVVSGVQH QSTLELSEVG VEAAAATSIA MSRMSLSSFS VNRPFLFFIF
   421  EDTTGLPLFV GSVRNPNPSA PRELKEQQDS PGNKDFLQSL KGFPRGDKLF GPDLKLVPPM
   481  EEDYPQFGSP K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
1,498 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,498 nTPM
  • epididymis: 96 nTPM
  • kidney: 70 nTPM
  • seminal vesicle: 31 nTPM
  • prostate: 20 nTPM
  • choroid plexus: 19 nTPM

Single-cell type

  • proximal tubule cells: 108 nCPM
  • renal collecting duct intercalated cells: 26 nCPM
  • choroid plexus epithelial cells: 17 nCPM
  • renal connecting tubule cells: 14 nCPM
  • hepatocytes: 11 nCPM
  • epididymal clear cells: 8.2 nCPM

Immune cell

  • plasmacytoid DC: 45 nTPM
  • myeloid DC: 11 nTPM
  • classical monocyte: 1.9 nTPM
  • eosinophil: 1.4 nTPM
  • NK-cell: 1.2 nTPM
  • total PBMC: 1.2 nTPM

Brain region

  • choroid plexus: 21 nTPM
  • white matter: 3.1 nTPM
  • cerebral cortex: 2.7 nTPM
  • hippocampal formation: 2.7 nTPM
  • thalamus: 2.4 nTPM
  • pons: 2.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SERPINF2.

Disease | AllUniProt

Conditions SERPINF2 is implicated in, by any mechanism.

  • Alpha-2-plasmin inhibitor deficiency (APLID) MIM:262850

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 112 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0.01
gnomAD missense Z
1.23
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINF2 as an antibody target. Whether an autoantibody or antibody against SERPINF2 could matter depends on whether native SERPINF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINF2 is annotated as secreted, so native SERPINF2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SERPINF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SERPINF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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