Seroatlas · Human Serome Atlas

SERPINA11

Serpin A11

Also known as: SPA11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86U17
Gene: SERPINA11
Ensembl: ENSG00000186910
Chromosome: 14
Canonical length: 422 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q86U17|SERPINA11
     1  MGPAWLWLLG TGILASVHCQ PLLAHGDKSL QGPQPPRHQL SEPAPAYHRI TPTITNFALR
    61  LYKELAADAP GNIFFSPVSI STTLALLSLG AQANTSALIL EGLGFNLTET PEADIHQGFR
   121  SLLHTLALPS PKLELKVGNS LFLDKRLKPR QHYLDSIKEL YGAFAFSANF TDSVTTGRQI
   181  NDYLRRQTYG QVVDCLPEFS QDTFMVLANY IFFKAKWKHP FSRYQTQKQE SFFVDERTSL
   241  QVPMMHQKEM HRFLYDQDLA CTVLQIEYRG NALALLVLPD PGKMKQVEAA LQPQTLRKWG
   301  QLLLPSLLDL HLPRFSISGT YNLEDILPQI GLTNILNLEA DFSGVTGQLN KTISKVSHKA
   361  MVDMSEKGTE AGAASGLLSQ PPSLNTMSDP HAHFNRPFLL LLWEVTTQSL LFLGKVVNPV
   421  AG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINA11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 459 nTPM

Expression across tissuesHPA

Tissue

liver: 459 nTPM
cervix: 4.9 nTPM
salivary gland: 3.7 nTPM
breast: 2.7 nTPM
esophagus: 0.5 nTPM
endometrium: 0.4 nTPM

Single-cell type

hepatocytes: 272 nCPM
hepatic stellate cells: 13 nCPM
breast hormone-responsive cells: 11 nCPM
innate lymphoid cells: 9.5 nCPM
submucosal glandular cells: 7.7 nCPM
kupffer cells: 4.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SERPINA11.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Pericardial effusion
Pleural effusion

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: 0.21
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINA11 as an antibody target. Whether an autoantibody or antibody against SERPINA11 could matter depends on whether native SERPINA11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINA11 is annotated as secreted, so native SERPINA11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SERPINA11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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