Seroatlas · Human Serome Atlas

SERPINA13P

Putative serpin A13

Also known as: SPA13_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXR4
Gene: SERPINA13P
Canonical length: 307 aa

OverviewNCBI Gene

No narrative summary is available for SERPINA13P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q6UXR4|SERPINA13P
     1  MEASRWWLLV TVLMAGAHCV ALVDQEASDL IHSGPQDSSP GPALPCHKIS VSNIDFAFKL
    61  YRQLALNAPG ENILFFPVSI SLALAMLSWG APVASRTQLL EGLGFTLTVV PEEEIQEGFW
   121  DLLIRLRGQG PRLLLTMDQR RFSGLGARAN QSLEEAQKHI DEYTEQQTQG KLGAWEKDLG
   181  SETTAVLVNH MLLRAEWMKP FDSHATSPKE FFVDEHSAVW VPMMKEKASH RFLHDRELQC
   241  SVLRMDHAGN TTTFFIFPNR GKMRHLEDAL LPETLIKWDS LLRTRELDFH FPKFSISRTC
   301  RLEMLLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERPINA13P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERPINA13P as an antibody target. Whether an autoantibody or antibody against SERPINA13P could matter depends on whether native SERPINA13P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERPINA13P is annotated as secreted, so native SERPINA13P circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SERPINA13P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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