GPCR family 2, extracellular hormone receptor domain superfamily

Definition

This domain superfamily is found in the extracellular part of some of the secretin-like (family 2) GPCRs including the corticotropin releasing factor receptor 1; calcitonin receptor; diuretic hormone receptor; glucagon-like peptide 1 receptor; and parathyroid hormone peptide receptor. The N-terminal extracellular domain is the major ligand recognition domain PMID:15326300. This domain structure has a disulfide-rich all-β fold and contains a β sandwich of 5 strands.

28 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (28 proteins: gene, accession, name)

• ADCYAP1R1
• ADGRA2
• ADGRA3
• ADGRB1
• ADGRB2
• ADGRB3
• ADGRF3
• ADGRG4
• ADGRL1
• ADGRL2
• ADGRL3
• CALCR
• CALCRL
• CELSR1
• CELSR2
• CELSR3
• CRHR1
• CRHR2
• GCGR
• GHRHR
• GIPR
• GLP1R
• GLP2R
• PTH1R
• PTH2R
• SCTR
• VIPR1
• VIPR2