Serpin domain
IPR023796
Definition
This entry represents the structural domain of serpins. Serpins (SERine Proteinase INhibitors) belong to MEROPS inhibitor family I4, clan ID. Most serpin family members are indeed serine protease inhibitors, but several have additional cross-class inhibition functions and inhibit cysteine protease family members such as the caspases and cathepsins [[cite:PMID:8034697], [cite:PMID:7851535]]. Others, such as ovalbumin, are incapable of protease inhibition and serve other functions PMID:8417965.
38 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (38 proteins: gene, accession, name)
- AGT
- HMSD
- SERPINA1
- SERPINA10
- SERPINA11
- SERPINA12
- SERPINA13P
- SERPINA2
- SERPINA3
- SERPINA4
- SERPINA5
- SERPINA6
- SERPINA7
- SERPINA9
- SERPINB1
- SERPINB10
- SERPINB11
- SERPINB12
- SERPINB13
- SERPINB2
- SERPINB3
- SERPINB4
- SERPINB5
- SERPINB6
- SERPINB7
- SERPINB8
- SERPINB9
- SERPINC1
- SERPIND1
- SERPINE1
- SERPINE2
- SERPINE3
- SERPINF1
- SERPINF2
- SERPING1
- SERPINH1
- SERPINI1
- SERPINI2
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