Seroatlas · Human Serome Atlas

SUPT7L

STAGA complex 65 subunit gamma

Also known as: KIAA0764, SPT7L, ST65G_HUMAN, STAF65, STAF65gamma

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94864
Gene: SUPT7L
Ensembl: ENSG00000119760
Chromosome: 2
Canonical length: 414 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>O94864|SUPT7L
     1  MNLQRYWGEI PISSSQTNRS SFDLLPREFR LVEVHDPPLH QPSANKPKPP TMLDIPSEPC
    61  SLTIHTIQLI QHNRRLRNLI ATAQAQNQQQ TEGVKTEESE PLPSCPGSPP LPDDLLPLDC
   121  KNPNAPFQIR HSDPESDFYR GKGEPVTELS WHSCRQLLYQ AVATILAHAG FDCANESVLE
   181  TLTDVAHEYC LKFTKLLRFA VDREARLGQT PFPDVMEQVF HEVGIGSVLS LQKFWQHRIK
   241  DYHSYMLQIS KQLSEEYERI VNPEKATEDA KPVKIKEEPV SDITFPVSEE LEADLASGDQ
   301  SLPMGVLGAQ SERFPSNLEV EASPQASSAE VNASPLWNLA HVKMEPQESE EGNVSGHGVL
   361  GSDVFEEPMS GMSEAGIPQS PDDSDSSYGS HSTDSLMGSS PVFNQRCKKR MRKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUPT7L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

retina: 51 nTPM
pituitary gland: 45 nTPM
cerebellum: 44 nTPM
choroid plexus: 43 nTPM
spleen: 40 nTPM
ovary: 39 nTPM

Single-cell type

syncytiotrophoblasts: 52 nCPM
cytotrophoblasts: 42 nCPM
cone photoreceptor cells: 41 nCPM
extravillous trophoblasts: 41 nCPM
early primary spermatocytes: 39 nCPM
oocytes: 37 nCPM

Immune cell

basophil: 30 nTPM
NK-cell: 23 nTPM
myeloid DC: 21 nTPM
MAIT T-cell: 21 nTPM
memory CD8 T-cell: 19 nTPM
gdT-cell: 18 nTPM

Brain region

choroid plexus: 52 nTPM
white matter: 43 nTPM
cerebral cortex: 40 nTPM
hypothalamus: 40 nTPM
thalamus: 38 nTPM
midbrain: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SUPT7L.

Disease | AllUniProt

Conditions SUPT7L is implicated in, by any mechanism.

Fischer-Zirnsak progeroid syndrome (FZPS) MIM:621130

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 76 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Fischer-Zirnsak progeroid syndrome

Disease | ImmuneIEDB

Conditions an epitope on SUPT7L was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.05
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Bromodomain associated domain
Histone-fold
Bromodomain associated
STAGA complex 65 subunit gamma/SAGA complex subunit Spt7

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUPT7L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUPT7L as an antibody target. Whether an autoantibody or antibody against SUPT7L could matter depends on whether native SUPT7L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUPT7L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUPT7L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...