Seroatlas · Human Serome Atlas

TAF1C

TATA box-binding protein-associated factor RNA polymerase I subunit C

Also known as: MGC:39976, SL1, TAF1C_HUMAN, TAFI110, TAFI95

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15572
Gene: TAF1C
Ensembl: ENSG00000103168
Chromosome: 16
Canonical length: 869 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

869 residues, UniProt reviewed canonical sequence.

>Q15572|TAF1C
     1  MDFPSSLRPA LFLTGPLGLS DVPDLSFMCS WRDALTLPEA QPQNSENGAL HVTKDLLWEP
    61  ATPGPLPMLP PLIDPWDPGL TARDLLFRGG CRYRKRPRVV LDVTEQISRF LLDHGDVAFA
   121  PLGKLMLENF KLEGAGSRTK KKTVVSVKKL LQDLGGHQPW GCPWAYLSNR QRRFSILGGP
   181  ILGTSVASHL AELLHEELVL RWEQLLLDEA CTGGALAWVP GRTPQFGQLV YPAGGAQDRL
   241  HFQEVVLTPG DNPQFLGKPG RIQLQGPVRQ VVTCTVQGES KALIYTFLPH WLTCYLTPGP
   301  FHPSSALLAV RSDYHCAVWK FGKQWQPTLL QAMQVEKGAT GISLSPHLPG ELAICSRSGA
   361  VCLWSPEDGL RQIYRDPETL VFRDSSSWRW ADFTAHPRVL TVGDRTGVKM LDTQGPPGCG
   421  LLLFRLGAEA SCQKGERVLL TQYLGHSSPK CLPPTLHLVC TQFSLYLVDE RLPLVPMLKW
   481  NHGLPSPLLL ARLLPPPRPS CVQPLLLGGQ GGQLQLLHLA GEGASVPRLA GPPQSLPSRI
   541  DSLPAFPLLE PKIQWRLQER LKAPTIGLAA VVPPLPSAPT PGLVLFQLSA AGDVFYQQLR
   601  PQVDSSLRRD AGPPGDTQPD CHAPTASWTS QDTAGCSQWL KALLKVPLAP PVWTAPTFTH
   661  RQMLGSTELR REEEEGQRLG VLRKAMARGQ LLLQRDLGSL PAAEPPPAPE SGLEDKLSER
   721  LGEAWAGRGA AWWERQQGRT SEPGRQTRRP KRRTQLSSSF SLSGHVDPSE DTSSPHSPEW
   781  PPADALPLPP TTPPSQELTP DACAQGVPSE QRQMLRDYMA KLPPQRDTPG CATTPPHSQA
   841  SSVRATRSQQ HTPVLSSSQP LRKKPRMGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

spleen: 31 nTPM
ovary: 30 nTPM
kidney: 24 nTPM
endometrium: 24 nTPM
cervix: 23 nTPM
thyroid gland: 23 nTPM

Single-cell type

tuft cells: 46 nCPM
astrocytes: 34 nCPM
proximal tubule cells: 28 nCPM
vascular endothelial cells: 27 nCPM
oligodendrocyte progenitor cells: 26 nCPM
bergmann glia: 26 nCPM

Immune cell

MAIT T-cell: 1.8 nTPM
gdT-cell: 1.5 nTPM
myeloid DC: 1.5 nTPM
NK-cell: 1.5 nTPM
classical monocyte: 1.3 nTPM
intermediate monocyte: 1.3 nTPM

Brain region

hippocampal formation: 26 nTPM
medulla oblongata: 25 nTPM
basal ganglia: 24 nTPM
amygdala: 24 nTPM
cerebral cortex: 22 nTPM
thalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: -2.29
DepMap mean gene effect: -1.08
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
TATA box-binding protein-associated factor RNA polymerase I subunit C
TAF1C, beta-propeller domain
TAF1C, C-terminal domain
TAF1C, helical bundle domain
TAF1C, beta-propeller
TAF1C, helical bundle domain
TAF1C, C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF1C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF1C as an antibody target. Whether an autoantibody or antibody against TAF1C could matter depends on whether native TAF1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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