TAF6

Protein identityUniProt · HPA

UniProt accession

P49848

Gene

TAF6

Ensembl

ENSG00000106290

Chromosome

7

Canonical length

677 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

677 residues, UniProt reviewed canonical sequence.

>P49848|TAF6
     1  MAEEKKLKLS NTVLPSESMK VVAESMGIAQ IQEETCQLLT DEVSYRIKEI AQDALKFMHM
    61  GKRQKLTTSD IDYALKLKNV EPLYGFHAQE FIPFRFASGG GRELYFYEEK EVDLSDIINT
   121  PLPRVPLDVC LKAHWLSIEG CQPAIPENPP PAPKEQQKAE ATEPLKSAKP GQEEDGPLKG
   181  KGQGATTADG KGKEKKAPPL LEGAPLRLKP RSIHELSVEQ QLYYKEITEA CVGSCEAKRA
   241  EALQSIATDP GLYQMLPRFS TFISEGVRVN VVQNNLALLI YLMRMVKALM DNPTLYLEKY
   301  VHELIPAVMT CIVSRQLCLR PDVDNHWALR DFAARLVAQI CKHFSTTTNN IQSRITKTFT
   361  KSWVDEKTPW TTRYGSIAGL AELGHDVIKT LILPRLQQEG ERIRSVLDGP VLSNIDRIGA
   421  DHVQSLLLKH CAPVLAKLRP PPDNQDAYRA EFGSLGPLLC SQVVKARAQA ALQAQQVNRT
   481  TLTITQPRPT LTLSQAPQPG PRTPGLLKVP GSIALPVQTL VSARAAAPPQ PSPPPTKFIV
   541  MSSSSSAPST QQVLSLSTSA PGSGSTTTSP VTTTVPSVQP IVKLVSTATT APPSTAPSGP
   601  GSVQKYIVVS LPPTGEGKGG PTSHPSPVPP PASSPSPLSG SALCGGKQEA GDSPPPAPGT
   661  PKANGSQPNS GSPQPAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.5

Highest tissue expression

35 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAF6.

Disease | AllUniProt

Conditions TAF6 is implicated in, by any mechanism.

• Alazami-Yuan syndrome (ALYUS) MIM:617126

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 226 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Alazami-Yuan syndrome
• Cornelia de Lange syndrome 1
• Inborn genetic diseases
• Gastric cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.78

gnomAD pLI

0

gnomAD missense Z

1.97

DepMap mean gene effect

-1.41

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• DNA-templated transcription initiation
• mRNA transcription by RNA polymerase II
• negative regulation of cell cycle
• negative regulation of cell population proliferation
• positive regulation of apoptotic process
• positive regulation of DNA-templated transcription
• positive regulation of intrinsic apoptotic signaling pathway
• positive regulation of transcription initiation by RNA polymerase II
• regulation of DNA repair
• regulation of transcription by RNA polymerase II
• RNA polymerase II preinitiation complex assembly
• transcription by RNA polymerase II
• transcription initiation at RNA polymerase II promoter

Molecular functions

• aryl hydrocarbon receptor binding
• DNA binding
• protein heterodimerization activity
• RNA polymerase II general transcription initiation factor activity
• transcription coactivator activity

Cellular components

• cytosol
• MLL1 complex
• nucleoplasm
• nucleus
• protein-containing complex
• SAGA complex
• SLIK (SAGA-like) complex
• transcription factor TFIID complex
• transcription factor TFTC complex

Protein domainsUniProt · Pfam · InterPro

• TATA box binding protein associated factor (TAF), histone-like fold domain
• Histone-fold
• TAF6, C-terminal HEAT repeat domain
• Armadillo-type fold
• Transcription initiation factor TFIID subunit 6
• TAF6, C-terminal HEAT repeat domain superfamily
• TATA box binding protein associated factor (TAF)
• TAF6 C-terminal HEAT repeat domain

KeywordsUniProt

• Apoptosis
• Intellectual disability
• Isopeptide bond
• Methylation
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of TAF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TBP
• TAF8
• TAF12
• TAF5