Seroatlas · Human Serome Atlas

TAF10

Transcription initiation factor TFIID subunit 10

Also known as: TAF10_HUMAN, TAF2A, TAF2H, TAFII30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q12962
Gene
TAF10
Ensembl
ENSG00000166337
Chromosome
11
Canonical length
218 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>Q12962|TAF10
     1  MSCSGSGADP EAAPASAASA PGPAPPVSAP AALPSSTAAE NKASPAGTAG GPGAGAAAGG
    61  TGPLAARAGE PAERRGAAPV SAGGAAPPEG AISNGVYVLP SAANGDVKPV VSSTPLVDFL
   121  MQLEDYTPTI PDAVTGYYLN RAGFEASDPR IIRLISLAAQ KFISDIANDA LQHCKMKGTA
   181  SGSSRSKSKD RKYTLTMEDL TPALSEYGIN VKKPHYFT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
148 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 148 nTPM
  • pancreas: 108 nTPM
  • testis: 106 nTPM
  • liver: 97 nTPM
  • adrenal gland: 94 nTPM
  • heart muscle: 92 nTPM

Single-cell type

  • late spermatids: 302 nCPM
  • megakaryocytes: 204 nCPM
  • cardiomyocytes: 156 nCPM
  • epididymal principal cells: 68 nCPM
  • epicardial cells: 59 nCPM
  • early spermatids: 55 nCPM

Immune cell

  • neutrophil: 21 nTPM
  • plasmacytoid DC: 19 nTPM
  • non-classical monocyte: 12 nTPM
  • intermediate monocyte: 11 nTPM
  • basophil: 9.2 nTPM
  • naive B-cell: 9.2 nTPM

Brain region

  • pons: 59 nTPM
  • cerebral cortex: 59 nTPM
  • medulla oblongata: 58 nTPM
  • midbrain: 56 nTPM
  • hypothalamus: 55 nTPM
  • thalamus: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.88
gnomAD missense Z
0.84
DepMap mean gene effect
-0.73
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transcription initiation factor TFIID, subunit 10
  • Transcription initiation factor TFIID 23-30kDa subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF10 as an antibody target. Whether an autoantibody or antibody against TAF10 could matter depends on whether native TAF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAF10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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