TAF7
Transcription initiation factor TFIID subunit 7
Also known as: TAF2F, TAF7_HUMAN, TAFII55
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15545
- Gene
- TAF7
- Ensembl
- ENSG00000178913
- Chromosome
- 5
- Canonical length
- 349 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Golgi apparatus
OverviewNCBI Gene
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
349 residues, UniProt reviewed canonical sequence.
>Q15545|TAF7
1 MSKSKDDAPH ELESQFILRL PPEYASTVRR AVQSGHVNLK DRLTIELHPD GRHGIVRVDR
61 VPLASKLVDL PCVMESLKTI DKKTFYKTAD ICQMLVSTVD GDLYPPVEEP VASTDPKASK
121 KKDKDKEKKF IWNHGITLPL KNVRKRRFRK TAKKKYIESP DVEKEVKRLL STDAEAVSTR
181 WEIIAEDETK EAENQGLDIS SPGMSGHRQG HDSLEHDELR EIFNDLSSSS EDEDETQHQD
241 EEDINIIDTE EDLERQLQDK LNESDEQHQE NEGTNQLVMG IQKQIDNMKG KLQETQDRAK
301 RQEDLIMKVE NLALKNRFQA VLDELKQKED REKEQLSSLQ EELESLLEKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 139 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 139 nTPM
- tongue: 122 nTPM
- thymus: 112 nTPM
- heart muscle: 97 nTPM
- ovary: 95 nTPM
- retina: 89 nTPM
Single-cell type
- esophageal apical cells: 346 nCPM
- neutrophils: 303 nCPM
- ovarian stromal cells: 229 nCPM
- epididymal principal cells: 210 nCPM
- decidual stromal cells: 182 nCPM
- syncytiotrophoblasts: 175 nCPM
Immune cell
- basophil: 186 nTPM
- eosinophil: 165 nTPM
- neutrophil: 98 nTPM
- NK-cell: 91 nTPM
- naive CD4 T-cell: 86 nTPM
- naive CD8 T-cell: 75 nTPM
Brain region
- white matter: 79 nTPM
- cerebellum: 67 nTPM
- choroid plexus: 66 nTPM
- spinal cord: 60 nTPM
- cerebral cortex: 59 nTPM
- hypothalamus: 54 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.41
- gnomAD pLI
- 0.89
- gnomAD missense Z
- 1.74
- DepMap mean gene effect
- -0.78
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- chromatin organization
- DNA-templated transcription initiation
- estrogen receptor signaling pathway
- mRNA transcription by RNA polymerase II
- negative regulation of DNA-templated transcription
- negative regulation of MHC class II biosynthetic process
- negative regulation of protein kinase activity
- negative regulation of transcription by RNA polymerase II
- positive regulation of DNA-templated transcription
- positive regulation of transcription by RNA polymerase II
- positive regulation of transcription initiation by RNA polymerase II
- regulation of DNA repair
- regulation of transcription by RNA polymerase II
- RNA polymerase II preinitiation complex assembly
- spermine transport
- transcription by RNA polymerase II
- transcription initiation at RNA polymerase II promoter
- negative regulation of MHC class I biosynthetic process
Molecular functions
- DNA-binding transcription factor binding
- histone acetyltransferase binding
- nuclear thyroid hormone receptor binding
- nuclear vitamin D receptor binding
- P-TEFb complex binding
- protein heterodimerization activity
- RNA polymerase II general transcription initiation factor activity
- TFIIH-class transcription factor complex binding
- transcription cis-regulatory region binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TAF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAF7 as an antibody target. Whether an autoantibody or antibody against TAF7 could matter depends on whether native TAF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TAF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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