Seroatlas · Human Serome Atlas

SLC30A4

Probable proton-coupled zinc antiporter SLC30A4

Also known as: ZNT4, ZNT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14863
Gene: SLC30A4
Ensembl: ENSG00000104154
Chromosome: 15
Canonical length: 429 aa
Protein class: Plasma proteins, Predicted membrane proteins, Transporters
Quaternary structure: Homodimer

OverviewNCBI Gene

Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>O14863|SLC30A4
     1  MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV ADDGSEAPER
    61  PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK QREILKQRKV KARLTIAAVL
   121  YLLFMIGELV GGYIANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTK RFTFGFHRLE
   181  VLSAMISVLL VYILMGFLLY EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG
   241  HRHSHSHSLP SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE
   301  YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK IEDVYSVEDL
   361  NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT FGMYRCTIQL QSYRQEVDRT
   421  CANCQSSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC30A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

prostate: 37 nTPM
small intestine: 8 nTPM
duodenum: 6.5 nTPM
testis: 5.9 nTPM
basal ganglia: 5.1 nTPM
thyroid gland: 4.4 nTPM

Single-cell type

prostatic glandular cells: 747 nCPM
late spermatids: 144 nCPM
late primary spermatocytes: 104 nCPM
early spermatids: 98 nCPM
enterocytes: 72 nCPM
endometrial secretory cells: 64 nCPM

Immune cell

naive B-cell: 3.5 nTPM
gdT-cell: 2.2 nTPM
MAIT T-cell: 2.1 nTPM
naive CD8 T-cell: 2.1 nTPM
memory B-cell: 2 nTPM
memory CD4 T-cell: 1.5 nTPM

Brain region

basal ganglia: 25 nTPM
white matter: 20 nTPM
cerebral cortex: 17 nTPM
thalamus: 13 nTPM
cerebellum: 12 nTPM
midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.12
gnomAD missense Z: 1.05
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC30A4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC30A4 as an antibody target. Whether an autoantibody or antibody against SLC30A4 could matter depends on whether native SLC30A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC30A4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC30A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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